Unit:
Κατεύθυνση Μοριακή και Εφαρμοσμένη ΦυσιολογίαLibrary of the School of Health Sciences
Supervisors info:
Κοτσιφάκη Ελένη αναπληρώτρια καθηγήτρια
Original Title:
O ρόλος των μικροσωματιδίων στις ρευματικές νόσους
Summary:
Μicroparticles (MPs) are small membraned bound vesicles that arise from
activated and dying cells that incorporate nuclear, cytoplasmic and membrane
molecules as they detach from cells. A great number of studies indicate that
MPs are important mediators of cellular interactions and communication.They can
transfer bioactive molecules between cells as well as regulate diverse
processes such as inflammation, coagulation, vascular function and apoptosis.
In view of these activities MPs play a role in pathogenesis of rheumatic
diseases they represent novel biomarkers that they can be used to access events
in otherwise inaccessible tissues.
Aim of this thesis is consider the origin and biological activity of MPs. It
will further define the pathogenetic role of MPs in rheumatic diseases, their
role as biomarkers and explore therapeutic strategies to block their release of
signalling properties.
Keywords:
Microparticles, Biomarkers, Rheumatic diseases, Inflammation, Autoimmunity
Number of references:
205
