Unit:
Κατεύθυνση Περιοδοντολογία (Κλινικές Ειδικεύσεις)Βιβλιοθήκη Οδοντιατρικής
Supervisors info:
Ξανθίππη Δερέκα, Ιωάννης Βρότσος, Κλεοπάτρα Μαρκοπούλου
Original Title:
Διερεύνηση δραστικότητας εκκριτικής φωσφολιπάσης Α2 (sPLA2) και της συνδεδεμένης με λιποπρωτεΐνες φωσφολιπάσης Α2 (Lp-PLA2) στο ουλικό υγρό και τον ορό περιοδοντικών ασθενών πριν και μετά τη μη χειρουργική περιοδοντική θεραπεία
Summary:
Backround: Secreted phospholipases A2 (sPLA2) are inflammatory enzymes and
their elevated levels have been correlated with systemic inflammatory and
cardiovascular diseases. Lipoprotein-associated phospholipase A2 (Lp-PLA2) has
been characterized as an independent risk factor for cardiovascular diseases
and the elevated levels of Lp-PLA2 have been correlated with increased
incidence of cardiovascular diseases. Aim: The aim of this study is to
investigate a) the levels of sPLA2 and Lp-PLA2 in the serum and gingival
crevicular fluid of patients with chronic periodontitis and healthy controls
and b) the effect of non surgical periodontal therapy on the activity of sPLA2
and Lp-PLA2 levels in the serum and gingival crevicular fluid of periodontally
affected patients.
Materials and Methods: 10 systemically healthy subjects with advanced
periodontal disease and 10 systemically and periodontally healthy persons
participated in this pilot study. The activity of sPLA2 and Lp-PLA2 was then
determined in GCF and blood serum.
Results: The levels of sPLA2 and Lp-PLA2 activity in the gingival crevicular
fluid and serum of periodontal patients were statistically significant elevated
compared to those of controls. Non surgical periodontal therapy significantly
reduced the levels of sPLA2 in GCF but not in serum of periodontal patients.
Non surgical periodontal therapy had not a significant effect on Lp-PLA2 levels
in GCF and serum.
Conclusion: Within the limitations of this pilot study, the levels of sPLA2 and
Lp-PLA2 activity were found both topically and systemically elevated in
periodontal patients compared to those of the control group and it seems that
non surgical periodontal therapy reduces only the sPLA2 levels in GCF of
periodontal patients.
Keywords:
Secreted phospholipase A2, Lp-phospholipase A2, Crevicular fluid, Periodontal therapy
