Επιπλοκές του στόματος σε ασθενείς με καρκίνο κεφαλής-τραχήλου που υπεβλήθησαν σε ακτινοθεραπεία, με ή χωρίς χημειοθεραπεία

Postgraduate Thesis uoadl:1315281 629 Read counter

Unit:
Κατεύθυνση Παθοβιολογία Στόματος
Βιβλιοθήκη Οδοντιατρικής
Deposit date:
2015-04-27
Year:
2014
Author:
Μαρούκης Βασίλειος
Supervisors info:
Νικολάτου-Γαλίτη Ουρανία, Καθηγήτρια, Δοντά Αικατερίνη,Επίκουρη Καθηγήτρια, Γκουτζάνης Λάμπρος, Λέκτορας
Original Title:
Επιπλοκές του στόματος σε ασθενείς με καρκίνο κεφαλής-τραχήλου που υπεβλήθησαν σε ακτινοθεραπεία, με ή χωρίς χημειοθεραπεία
Languages:
Greek
Summary:
INTRODUCTION : Treatment of head and neck cancer is multifaceted and combines
surgical excisition, chemotherapy and radiotherapy. Despite the effectiveness
of the treatment schemes, sideffects such as oral mucositis, candidiasis,
herpes infection and xerostomia, are likely to occur, adversely affecting
treatment outcome and patients quality of life.

PURPOSE : To compare the severity of oral mucositis, pain and xerostomia and to
evaluate the effects of fungal and viral infection of patients with head and
neck cancer, during and at the completion of radiotherapy.

PATIENTS AND METHODS : The clinical records of 176 patients with head and
neck cancer, who underwent radiotherapy with or without chemotherapy, during
the period 2008-2012 were evaluated from the Hospital Dentistry Clinic of
Dental School of National and Kapodistrian University of Athens.

RESULTS : From 176 patients patients with head and neck cancer who underwent
radiotherapy with or without chemotherapy during the period 2008-2012, oral
mucositis, grade 2,3 and 4 was developed in 82,9% of patients during the course
of the radiotherapy. Mild xerostomia was developed in 22,7%, moderate in 30,7%
and severe in 46,6%. Respectively, mild intensity pain was noted in 32,9%,
moderate intensity in 27.9% and severe intensity pain in 39,2% of the patients.
At the completion of the radiotherapy oral mucositis grade 2,3 and 4 was
evaluated in 56,8% of the patients. Mild xerostomia was noted in 36.9%,
moderate in 34.1% and severe in 29%. Respectively, mild intensity pain was
noted in 51.2%, moderate intensity in 24.4% and severe intensity pain in 24.4%
of the patients.


At the completion of the radiotherapy a reduction of the severity of oral
mucositis can be observed, althought its prevalence is still high. Severe pain
and xerostomia are also improved. Those results delineate the important role of
fungal and viral infections in the severety of oral mucositis, pain and
xerostomia. Mild intensity pain shows an increase. This can be attributed to
the fact that oral mucositis is improving but it hasn’t still fully healed.

CONCLUSIONS : The prevalence of head and neck cancer is higher in men than
women and it is more likely to occur in older individuals. Oral mucositis that
develops during the course of radiotherapy and chemotherapy does not have an
infectious origin and it is caused by the panmucosal damage that occurs during
the radio and chemotherapy. The ulcers of oral mucositis are likely to be
infected by fungi and viruses, an effect that can increase its severity.
Antifungal and antiviral treatment plays an important role in controling
mucositis severity. Fungal infections of mucositis during the course of
radiotherapy is facilitated also by the upcoming xerostomia which develops from
the irradiation of the salivaly glands. It is also worth mentioning that a
sudden increase in xerostomia in these patients can be attributed to an ongoing
fungal infection.
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
94
Number of pages:
75
File:
File access is restricted.

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