Η επίδραση της περιοδοντικής θεραπείας σε κλινικές και εργαστηριακές παραμέτρους ασθενών με ρευματοειδή αρθρίτιδα και χρόνια περιοδοντίτιδα

Postgraduate Thesis uoadl:1315296 352 Read counter

Unit:
Κατεύθυνση Περιοδοντολογία (Κλινικές Ειδικεύσεις)
Βιβλιοθήκη Οδοντιατρικής
Deposit date:
2015-04-22
Year:
2015
Author:
Κοτσάνη Αγγελική
Supervisors info:
Ιωάννης Βρότσος Καθηγητής, Φοίβος Μαδιανός Καθηγητής, Βασίλειος Πανής Αναπληρωτής Καθηγητής
Original Title:
Η επίδραση της περιοδοντικής θεραπείας σε κλινικές και εργαστηριακές παραμέτρους ασθενών με ρευματοειδή αρθρίτιδα και χρόνια περιοδοντίτιδα
Languages:
Greek
Summary:
Aim: the aim of this pilot study was to assess the effect of non-surgical
periodontal therapy on the severity of active RA in patients with chronic
periodontal disease.
Materials & methods: 14 patients with mild-to-moderate chronic periodontitis
were enrolled: 7 patients with confirmed diagnosis of RA (test group) and 7
systemically healthy patients (control group). All patients received
non-surgical periodontal therapy consisting of oral hygiene instructions and
full mouth planing and root scaling. Participants continued their usual
disease-modifying medications for RA without any changes in DMARD therapy
during the study period. Periodontal and rheumatologic parameters and serum
levels of CRP, ACCP, IL-17A were recorded at baseline and at 12 weeks later.
Results: the clinical periodontal parameters were statistically reduced for
both groups. IL-17A serum levels showed a statistically significant reduction
(p<0,05) only for the test group. A trend for reduction was noticed for hsCRP
and ACCP serum levels for the test group, without statistical significance. ESR
and DAS28 showed a slight increase for the test group.
Conclusion: non-surgical periodontal treatment seems to reduce serum levels of
CRP, ACCP and IL-17A, while does not affect DAS28 nor ESR.
Keywords:
Rheumatoid arthritis, Periodontal disease, Non-surgical periodontal therapy, IL-17
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
218
Number of pages:
135
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