Τομέας ΦΑΡΜΑΚΟΓΝΩΣΙΑΣ ΚΑΙ ΧΗΜΕΙΑΣ ΦΥΣΙΚΩΝ ΠΡΟΪΟΝΤΩΝ
Library of the School of Science

2011-10-06

2011

Σταματίου Ιωάννης

Βασίλειος Ρούσσης Καθηγητής Επιβλέπων, Όλγα Τζάκου Αναπλ. Καθηγήτρια, Αλέξιος-Λέανδρος Σκαλτσούνης Καθηγητής

Απομόνωση και ταυτοποίηση μεταβολιτών από το μαλακό κοράλλι SINULARIA LEPTOCLADOS

Greek

Soft corals have been reported to produce an impressive number and structural
variety of secondary metabolites with biological activities. The Indo–Pacific
genus Sinularia with approximately 130 species is the largest zooxanthellate
shallow–water soft coral genus. About 60 % of sinularin corals produce
serquiterpenes, diterpenes, nor-diterpenes, polyhydroxylated steroids and
polyamine compounds with antimicrobial, anti–inflammatory and cytotoxic
activities.
In the course of our investigations for the isolation of bioactive metabolites
from marine organisms, we undertook the study of S. leptoclados, collected in
the Egyptian coasts of the Red Sea in 2008. The organic extract was subjected
to a series of chromatographic separations to yield twelve steroids. Among
them, compound 9 is a new 5(67) abeo-sterol featuring a cyclopropane ring in
the side chain and compound 14 is a new metabolite of mixed biosynthesis.
The structures of the isolated natural products were determined on the basis of
extensive analysis of 1D and 2D NMR and MS data

Soft coral, Natural products, Marine organisms, Isolation, Pharmacognosy

No

0

Yes

82

VIII, 115

https://pergamos.lib.uoa.gr/uoa/dl/object/1316343/file.pdf

https://pergamos.lib.uoa.gr/uoa/dl/object/1316343