Unit:
Κατεύθυνση Οργανική ΧημείαLibrary of the School of Science
Supervisors info:
Θωμάς Μαυρομούστακος (Καθηγητής ΕΚΠΑ-Επιβλέπων), Γιώργος Λιαπάκης (Αναπληρωτής Καθηγητής Ιατρικής Σχολής Πανεπιστημίου Κρήτης), Θεόδωρος Τσέλιος (Αναπληρωτής Καθηγητής Χημικού Τμήματος Πανεπιστημίου Πατρών)
Original Title:
Διαμορφωτική Άνάλυση Βιοδραστικών Πεπτιδίων κατά της κατάθλιψης και της σκλήρυνσης κατά πλάκας
Translated title:
Conformational Analysis of peptides with potential bioactivity against depression and multiple sclerosis
Summary:
In this thesis, the conformations of bioactive peptides that may show
bioactivity against depression and multiple sclerosis were studied. The given
structures were structurally elucidated and their conformational analysis was
achieved using a combination of Nuclear Magnetic Resonance (NMR) spectroscopy
and in silico computational analysis. The acquired information on the peptide’s
conformational analysis gave important clues for the understanding of the
pharmacophore features responsible for their biological activity.
Keywords:
Nuclear Magnetic Resonance (NMR), Molecular Dynamics, Depression, Multiple Sclerosis, Epitope Of Myelin
Number of index pages:
1-9
