Κατεύθυνση Κλινική Φαρμακευτική
Library of the School of Science

2015-03-19

2015

Λυκίδης Βασίλειος

Κυρούδη-Μαρκαντώνη Σοφία Καθηγήτρια (Επιβλέπουσα),Βαλσαμή Γεωργία Αναπλ. Καθηγήτρια,Δοκουμετζίδης Αριστείδης Επίκ. Καθηγητής

Επίδραση της δικλοφενάκης μαζί με ακτινοβολία στο ακανθοκυτταρικό καρκίνωμα

Greek

The effect of diclofenac in combiantion with radiation on the squamus cell cancer.

Introduction: Squamous cell carcinoma is a non-melanomatic skin cancer which
affects the middle epidermis. Diclofenac is a non-steroidal-antiinflammatory
drug which inhibits the enzyme cyclooxygenase 2 (COX-2) and is considered to be
useful as short-term therapy to induce the recovery of precursor lesions in
squamous cell carcinoma. .
Purpose: The aim of this study was to examine the effectiveness of 3%
diclofenac cream in disease relapse (loco regional recurrence) of squamous cell
carcinoma in patients with squamous cell carcinoma of the head and neck.
Methods and Patients: 12 patients with squamous cell carcinoma of the head and
neck participated in the study. 3% diclofenac cream was applied to the affected
areas prior to radiation therapy with Roentgen rays for a total of 22 sessions.
2 years after therapy the patients were reexamined for relapses cases.
Results: 11 of the 12 patients showed no local relapses of the disease. Only
one patient exhibited relapse and this was attributed to the fact that he
suffered from nasal squamous cell carcinoma which is known to have a higher
relapse rate than other forms of the disease.

Squamus cell cancer, Diclofenac, Radiation, Reccurence, Cycloxygenase-2

No

0

Yes

15

54

File access is restricted.

https://pergamos.lib.uoa.gr/uoa/dl/object/1317409