Unit:
Τομέας ΒοτανικήςLibrary of the School of Science
Author:
Σεμανιάκου Πολιάνα
Supervisors info:
Παρασκευή Μουτσάτσου Αναπλ. Καθηγ.(Επιβλέπουσα), Ευανθία Κασσή Επικ. Καθηγ., Χρήστος Κρούπης Επικ. Καθηγ.
Original Title:
Μελέτη του υποδοχέα των γλυκοκορτικοειδών σε ασθενείς με σκλήρυνση κατά πλάκας
Translated title:
Study of the glucocrticoid receptor in patients with multiple sclerosis
Summary:
The purpose of the present study was: a) to determine the sequence of isoform α
of the GR gene in 20 DNA samples of patients with MS disease and the presence
of molecular alterations (mutations or polymorphisms) associated
with MS
disease, b) the correlation of molecular changes of glucocorticoid receptor to
the
response or not in administered methylprednisolone therapy and
clinical
improvement of patients with MS disease.
Keywords:
Glucocorticoids, Glucocorticoid receptor, Multiple sclerosis, Mutations, Polymorphisms
Number of references:
215