N-acetylserotonin:controlled release in aqueous media from hydrophilic matrix tablets

Postgraduate Thesis uoadl:1319136 368 Read counter

Unit:
Κατεύθυνση Βιομηχανική Φαρμακευτική
Library of the School of Science
Deposit date:
2015-02-02
Year:
2015
Author:
Φλιτούρη Στυλιανή
Supervisors info:
Μ. Βλάχου Επίκ. Καθηγήτρια ΕΚΠΑ (επιβλέπουσα) Α. Τσοτίνης Καθηγητής ΕΚΠΑ, . Κ. Δεμέτζος Καθηγητής ΕΚΠΑ
Original Title:
Ν-ακετυλοσεροτονίνη: μελέτες ελεγχόμενης αποδέσμευσής της από στερεές φαρμακοτεχνικές μορφές
Languages:
Greek
Translated title:
N-acetylserotonin:controlled release in aqueous media from hydrophilic matrix tablets
Summary:
N-acetylserotonin (NAS) is the immediate precursor of melatonin in its
biosynthetic route. It is synthesized in the mammalian pineal gland and the
retina. Experiments have also demonstrated that NAS acts in the hippocampus, in
the cerebellum, in the olfactory bulb and in the spinal cord. A very important
aspect of NAS biology, is the identification of its receptors, which modulate
different activities. NAS has some activity on the membrane G-protein-coupled
melatonin receptors-mainly MT3- on serotonin receptors and on TrkB receptors.
NAS binding to TrkB provides N-acetylserotonin neurotrophic, neuroprotective
and antidepressant properties. Furthermore, this molecule exhibit a
daily/circadian rhythm, a fact that connects NAS immediately with sleep
disorders, as melatonin.
In the context of this work a series of hydrophilic matrix tablets was prepared
and tested with respect to the controlled release of NAS. The prolonged release
contributes to a satisfactory connection with TrkB receptors and leads to a
successful confrontation of depression phenomena. The release of the active
ingredient was tested within a period of 8 hours in buffer solutions of pH=1.2
(gastric simulated fluid) and pH=7.4 (intestine simulated fluid). The results,
from a number of experiments, indicate that NAS in pH=1.2, is released in a
quick initial pace. Moreover, the % decrease of HPMC content, ameliorated to
some extent the release of NAS in the acid buffer solution. In general, in
pH=7.4, the % concentration of excipients in the tablets, does not seem to
affect either the pace or the amount of the active ingredient release. The
presence of dextran, as excipient in the tablets, does not appear to have a
significant effect on the release of NAS. Last, certain experiments indicate
that NAS is released in a quicker pace, compared to melatonin, in the gastric
simulated fluid.
Keywords:
N-acetylserotonin, Depression, Hydrophilic matrix, 5 hydroxytryptamine, Melatonin
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
175
Number of pages:
183
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