Κατεύθυνση Διδακτική της χημείας και νέες εκπαιδευτικές τεχνολογίες
Library of the School of Science

2016-07-06

2016

Καραπέτρος Πέτρος

Μαυρομούστακος Θωμάς Καθηγητής (επιβλέπων), Κορδάτος Κωνσταντίνος Αναπληρωτής Καθηγητής, Παρασκευοπούλου Πατρίνα Επίκουρος Καθηγήτρια

Οι έννοιες της οξύτητας και βασικότητας με πλαίσιο το φάρμακο

Greek

Acidity and basicity on the context of medical drugs

One of the universally encountered problems in education, is the not
recognition by the students of the significant role of chemistry in our
everyday life. Drugs are not only remedies but they can be used as
instructional tools to demonstrate many chemical principles in the high school
classroom. As the majority of drugs are weak acids and/or bases, knowledge of
the acidic or basic character of their functional groups helps in understanding
the ionic form a molecule will take across a range of pH values. This is
particularly important in physiological systems where ionization state will
affect the rate at which the compound is able to diffuse across membranes and
obstacles such as the blood-brain barrier. In addition, the ionization state of
a drug molecule influences lipophilicity, solubility, protein binding and
permeability. These physicochemical properties in turn directly affect either
pharmacokinetic characteristics such as absorption, distribution, metabolism
and excretion or pharmacodynamic features such as the formation of specific
types of interactions between the drug molecule and its biological target.
Relevance and context-based science education have been discussed as positive
influences on student’s engagement in science. It is commonly acceptable that
students’ interest is highly increasing when included topics in the classroom
encouraging connections with events experienced in their everyday lives.
Incorporating a theme of medicinal chemistry within a high school science
curriculum provides opportunities for relevant experimentation and the
potential to enhance student learning. The purpose of the dissertation is the
development of an instructional material which could be used in teaching both
chemical principles and concepts already included in Greek high school
secondary curriculum in the context of pharmacology. The instructional
material, which is characterized by interdisciplinary content, consists of
laboratory and hands on activities, handouts, and case-based worksheets for
particular drugs.

Drugs, Medicinal chemistry, Context-based learning, Acid/base chemistry, Pharmacokinetics/pharmacodynamics

Yes

16-25,310-312

Yes

145

329

File access is restricted.

https://pergamos.lib.uoa.gr/uoa/dl/object/1319244