Unit:
Τομέας Στατιστικής και Επιχειρησιακής ΈρευναςLibrary of the School of Science
Supervisors info:
Σιάννης Φώτιος Επίκ. Καθηγητής (Επιβλέπων), Μπουρνέτας Απόστολος Αναπλ. Καθηγητής, Μελιγκοτσίδου Λουκία Λέκτορας
Original Title:
Περιορισμένος Μέσος Χρόνος Επιβίωσης και Εφαρμογές στη Μετα-Ανάλυση
Translated title:
Restricted Mean Survival Time and Applications in Meta-Analysis
Summary:
Due to censoring it is impossible to observe the entire survival function.
Censored observations often gather in the tail of the survival curve as with
the passage of time increases the chance of losing a patient. This creates
serious complications in the calculation of mean survival time as we need to
have noticed the whole, or at least a very large part of the survival function,
for times that theoretically approaches infinity. This created the need for a
new measure which has the same module as the mean survival time and such an
interpretation. This idea was introduced in 1949 by Irwin and since then there
has been much progress on its interpretation and use in clinical studies.
In addition, in clinical trials in which two treatments are compared, if the
assumption of proportionality (proportionality) is violated, the Hazard Ratio
is not a stable measure for interpretation, although it is used extensively. On
the contrary the restricted mean survival time difference of the two treatments
(RMST difference) still gives interpretable results, which makes it remarkable
measure of paramount importance in randomized clinical trials.
Keywords:
Mean, Survival, Restricted, Meta-Analysis, Hazard
File:
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