Synthesis and characterization of hybrid block copolymers PEG-PHis bearing a folic acid molecule

Postgraduate Thesis uoadl:1320016 478 Read counter

Unit:
Κατεύθυνση Βιομηχανική Χημεία
Library of the School of Science
Deposit date:
2015-10-21
Year:
2015
Author:
Χριστακόπουλος Παναγιώτης
Supervisors info:
Ιατρού Ερμόλαος Καθηγητής
Original Title:
Σύνθεση και χαρακτηρισμός δισυσταδικών υβριδικών πολυμερών PEG-PHIS με φολικο οξύ
Languages:
Greek
Translated title:
Synthesis and characterization of hybrid block copolymers PEG-PHis bearing a folic acid molecule
Summary:
The main purpose of this thesis was the synthesis of hybrid copolymers that
carry a molecule of folic acid.
The synthesis of these molecules achieved in many steps and the chemical
modification of the end groups was required in order to synthesize these
molecules.
The polymerization of ethylene oxide was accomplished by the technique of
anionic polymerization, while the polymerization of histidine was accomplished
by the ring-opening polymerization. The successful polymerization of istidine
required the chemical modification of the end hydroxyl group of PEG into amino
group. Finally the folic acid molecule was added vy the technique of click
chemistry. The γ-carboxyl was modified into alkine and it was added to the
polymer through the azide that the molecule of PEG was carrying from initiator
in the anionic polymerization.
Molecular characterization was accomplished in order to verify the homogeneity
in composition and molecular weight for all samples and also to the successful
synthesis. Specifically, for the molecular characterization size exclusion
chromatography (SEC) at 350C, proton nuclear magnetic resonance spectroscopy
(1H-NMR), fourier transform infrared spectroscopy (FTIR) and ultraviolet–
visible spectroscopy (UV-Vis) were used and their results concluded to the
successful synthesis of all samples. All samples had narrow molecular
distributions without any traces of homopolymer in their final composition.
Keywords:
PEG, PHis, Anionic polymerization, Ring-opening polymerization, Click chemistry
Index:
Yes
Number of index pages:
1-9
Contains images:
Yes
Number of references:
236
Number of pages:
153
document.pdf (2 MB) Open in new window