Synthesis and Characterization of Multifunctional Copolymers of Poly(ethylene oxide), Polyhistidine and Polytyrosine. Aggregation phenomena in aqueous media.

Postgraduate Thesis uoadl:1320039 73 Read counter

Unit:
Κατεύθυνση Επιστήμη Πολυμερών και Εφαρμογές της
Library of the School of Science
Deposit date:
2016-06-29
Year:
2016
Author:
Λιάρου Ευαγγελία-Ελένη
Supervisors info:
Ερμόλαος Ιατρού Καθηγητής ΕΚΠΑ
Original Title:
Σύνθεση και Χαρακτηρισμός Πολυλειτουργικών Συμπολυμερών Πολυαιθυλενοξειδίου, Πολυιστιδίνης και Πολυτυροσίνης. Φαινόμενα συσσωμάτωσης σε υδατικά μέσα.
Languages:
Greek
Translated title:
Synthesis and Characterization of Multifunctional Copolymers of Poly(ethylene oxide), Polyhistidine and Polytyrosine. Aggregation phenomena in aqueous media.
Summary:
The current survey investigates the synthesis of a series of three
pH-responsive am-phiphilic block terpolymers, their role as multifunctional
polypeptide systems and their future potential as drug delivery systems. For
that reason, well-defined homo- and copolypeptides with controllable molecular
characteristics, were synthesized through Ring Opening Polymerization of
N-carboxyanhydrides of two α-amino acids (NCAs). For the synthesis of the
well-defined homopolymer of polytyrosine, the iniator that that was used was
the secondary amine, dimethyl-amine. Moreover, for the synthesis of the co- and
terpolymers, the iniator was the aminofunc-tionalized PEO-NH2. Furthermore,
herein, the synthesis of the Tyr(t-Bu)-OH NCA is presented for the first time
since, only the benzyl protecting group was used for this synthesis,
previously. High vacuum techniques were used for the purification of reagents,
solvents and for the synthesis of NCAs and polymers. In this way, the high
purity of monomers along with the high vacuum techniques resulted to the
synthesis of well-defined amphiphilic hybrid polymers of PTyr, PEO-b-PTyr, and
PEO-b-P(His-co-Tyr x), where x represents the molar percentage of tyrosine. The
results revealed that, the presence of tyrosine residues affected the secondary
structure of the polypeptide chain, promoting the beta sheet conformation and
gave the potential of a supersec-ondary structure as motif.
Keywords:
Multifunctional, Polypeptides, Self-assembly, Secondary structure, NCAs
Index:
Yes
Number of index pages:
1-8
Contains images:
Yes
Number of references:
112
Number of pages:
139
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