Κατεύθυνση Ανόργανη Χημεία και Τεχνολογία
Library of the School of Science

2015-11-09

2015

Στουραΐτης Αλέξανδρος

Κωνσταντίνος Μεθενίτης Αναπληρωτής Καθηγητής (Επιβλέπων), Μαρία Πελεκάνου Ερευνήτρια Α΄ ΕΚΕΦΕ "ΔΗΜΟΚΡΙΤΟΣ"

Σύνθεση και χαρακτηρισμός συμπλόκων του Ρηνίου(Ι) και Τεχνητίου(Ι) με πιθανές εφαρμογές στην Πυρηνική Ιατρική

Greek

Synthesis and characterization of Rhenium(I) and Technetium(I) complexes with applications in Nuclear Medicine

In this study, a number of Re(I) and metastable 99mTc(I) complexes are
synthesised, characterised and their biological activity evaluated for imaging
of certain types of cancer. The complexes incorporate the fac-[M(CO)3]+ (M = Re
ή 99mTc) core which stabilizes the two metals in the oxidation state (I). The
coordination sphere is completed with two ligands, one bidentate and the
other monodentate (“2+1” approach). The isocyano derivatives of 2-(4΄-
aminophenyl)benzothiazole (CJM 126) and
2-(4΄-amino-3-methylphenyl)benzothiazole (DF 203) are used as the monodentate
ligands because of their selective uptake and anticancer activity
against certain breast and ovarian cancer cell types. The resulting complexes
are expected to show selective uptake by cancer cells and therefore be suitable
for imaging of tumors either via γ-camera (99mTc complexes) or fluorescence
camera (Re complexes) due to the fluorescence of the phenylbenzothiazole
derivatives. Two β-diketones, acetylacetone and curcumin will be used as
bidentate ligands. Curcumin is a natural product extracted from the rhizome of
Curcuma Longa plant and possesses a wide range of
pharmaceutical properties, including anticancer, chemopreventive, antioxidant
and anti-inflammatory. The synthesis and characterisation of the complexes was
first carried out on
the stable, non radioactive rhenium. The complexes were characterised with
spectroscopic and chromatographic techniques like NMR and IR as well as X-ray
crystallography. Synthesis then proceeded on the metastable 99mTc level and
characterisation was performed by comparative chromatogaphy.

Rhenium complexes, Technetium complexes, Tricarbonyl metallic core, Benzothiazole, Nuclear Medicine

Yes

18-21

Yes

123

130

File access is restricted.

https://pergamos.lib.uoa.gr/uoa/dl/object/1320054