Synthesis of Cu(I) complexes and study of the biological activity towards cancer cells and PAF

Postgraduate Thesis uoadl:1320108 247 Read counter

Unit:
Κατεύθυνση Ανόργανη Χημεία και Τεχνολογία
Library of the School of Science
Deposit date:
2013-05-29
Year:
2013
Author:
Ξενικού Κυριακή
Supervisors info:
Καθηγήτρια ΕΚΠΑ, Χριστίνα-Άννα Μητσοπούλου
Original Title:
Σύνθεση συμπλόκων ενώσεων Cu(I) και μελέτη της βιολογικής τους δράσης έναντι καρκινικών κυττάρων και PAF
Languages:
Greek
Translated title:
Synthesis of Cu(I) complexes and study of the biological activity towards cancer cells and PAF
Summary:
In this thesis we carried out the synthesis and characterization of
[Cu(pq)2]BF4 and [Cu(pqCl)2]BF4 complexes using spectrophotometric methods like
NMR, F.T-IR, UV-Vis and CV. The complexes were studied in their interaction
with calf thymus DNA (C.T.-DNA). The interaction was studied with UV-Vis
spectrometry, Circular Dichroism, Viscometry, luminescence studies, Cyclic
Voltammetry and agaroze gel electrophoresis. All experiments were carried out
at pH=7 (tris HCl buffer). In addition, we studied the activity of [Cu(pq)
]BF4, [Cu(pqCl)2]BF4 and [Cu(dmp) ]BF4 as potential inhibitors towards Platelet
Activating Factor (PAF) as well as the biological effect of [Cu(pq) ]BF4
towards brain and prostate cancer cells.
Keywords:
Diimine complexes, Copper(I), DNA, PAF, Cancer cells
Index:
Yes
Number of index pages:
1-12
Contains images:
Yes
Number of references:
117
Number of pages:
136
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