Unit:
Κατεύθυνση Ανόργανη Χημεία και ΤεχνολογίαLibrary of the School of Science
Author:
Σταυράκη Αρσινόη- Ιωάννα
Supervisors info:
Χριστιάνα Μητσοπούλου Καθηγήτρια
Original Title:
Σύνθεση, Χαρακτηρισμός και Αλληλεπίδραση των Συμπλόκων [Cu(2,2'-bis-COOEtdppz)2](BF4) και [Cu(dppz)(dppe)](BF4) με DNA Μελέτη της κυτταροτοξικής τους δράσης.
Translated title:
Synthesis, Characterization and Interaction of [Cu(2,2'-bis-COOEtdppz)2](BF4) and [Cu(dppz)(dppe)](BF4) with DNA, studied also with cancer cells
Summary:
In the work presented in this thesis we carried out is the synthesis and
characterization of[Cu(2,2'-bis-COOEtdppz)2](BF4)and [Cu(dppz)(dppe)](BF4)
complexes. We also studied the interaction of these complexes with calf-thymus
DNA. We carried out viscosity experiments, electrophoresis,uv-VIS spectrometry
and other experiments. The results about the first complex is that interacts
with DNA throught intercalation. Concerning the second one, it interacts
throught electrostatic interaction. Both complexes gave very satisfying results
concerning the cancer cells they were studied with.
Keywords:
Copper, Photodynamic Therapy, DNA, Diimines, Complexes
Number of index pages:
1-9
