Supervisors info:
Π. Κυρίτσης Αναπλ. Καθηγητής (Επιβλέπων) , Κων/νος Μεθενίτης Αναπλ. Καθηγητής, Χ.-Α. Μητσοπούλου Καθηγήτρια
Summary:
n this work, the synthesis and characterization of the following Cu(II)
complexes, bearing the imidodiphosphinato ligand (O,O) =
[Ph2P(O)NP(O)Ph2][Σύμβολο] and various diimines, is presented:
[Cu{Ph2P(O)NP(O)Ph2}(2,2[Σύμβολο]-bipy)]NO3 (1),
[Cu{Ph2P(O)NP(O)Ph2}(1,10-phen)]NO3 (2),
[Cu2{Ph2P(O)NP(O)Ph2-O}2(1,10-phen)2(OH)2] (3),
[Cu{Ph2P(O)NP(O)Ph2}(neocuproine)]NO3 (4) and [Cu{Ph2P(O)NP(O)Ph2}(
curcuAX133)]NO3, (curcuAX133 = curcumine derivative) (5).
X-ray crystallographic studies on crystals of 1, 2 και 4 obtained by the
layering method (CH3OH/H2O 1:3) revealed a trigonal bipyramidal CuO3N2 first
coordination sphere. The structure is stabilized by intramolecular pi-pi
stacking, as well as by hydrogen bonds involving the coordinated H2O and Ο
atoms of the two [Ph2P(O)NP(O)Ph2][Σύμβολο] ligands, which, unexpectedly, are
coordinated in a monodentate fashion. Complex 3 is dinuclear, bearing two
bridging ΟΗ[Σύμβολο] between two Cu(II) centers.
UV-vis and cw EPR spectroscopy studies provided evidence that in solution
complexes 1, 2, 4 and 5 exhibit a tetragonal structure. Ligand super-hyperfine
interactions of the unpaired electron of 1 were investigated by pulsed ENDOR
and HYSCORE spectroscopies.
DNA-binding experiments showed that complex 1 induces conformational changes to
DNA. Moreover, this complex was shown to be cytotoxic towards the breast cancer
cell line MCF-7 and to inhibit the G2/M cycle transition.
Keywords:
Copper, DNA, Anticancer activity, Imidodiphosphinato ligand, Diimine
