Κατεύθυνση Βιομηχανική Φαρμακευτική
Library of the School of Science

2014-09-18

2014

Σβετζούρη Κυριακή

Εφεντάκης Εμμανουήλ Αναπλ. Καθηγητής

Σχεδιασμός, παρασκευή και αξιολόγηση διαφόρων μορφών παρατεταμένης αποδέσμευσης με δικλοφενάκη

Greek

Design, development and evaluation of various sustained-release systems with diclofenac.

This research, examines the design and the development of solid pharmaceutical
forms based on diclofenac. The sodium form of this active substance, has
already been used in trade forms of prolonged release. Based on this, the main
purposes of this study, are the design, the development , the evaluation and
the comparison of solid pharmaceutical forms with diclofenac sodium, and
specifically of single-unit tablets, multi-layered tablets and capsules with
microtablets or powder. All formulations achieved sustained release of
diclofenac, and completed within eight hours after taking per os. Finally,
after the evaluation of all solid forms, some of them were compared to a
commercial pharmaceutical product. Diclofenac sodium was combined with polymers
such as polyox, methocel and xanthan gum and the results were based on
dissolution and erosion studies. Xanthan gum caused the greatest prolonged
release of diclofenac in all tablets and capsules, while polyox had the
opposite effects. Also, diclofenac sodium was purely soluble in acid solution
pH 1.2 despite the use of surfactants in various ratios. Finally, two of these
polymers caused greater release than the trade formulation, while the
multi-layered tablets showed important differences in release behavior in
comparison with the respective capsules.

Diclofenac sodium, Sustained release, Multiple-unit systems, Dissolution, Erosion

No

0

Yes

32

175

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https://pergamos.lib.uoa.gr/uoa/dl/object/1320269