Unit:
Κατεύθυνση Βιομηχανική ΦαρμακευτικήLibrary of the School of Science
Author:
Φιλοπούλου Ευαγγελία
Supervisors info:
Μαχαίρας Παναγιώτης Καθηγητής (Επιβλέπων), Βαλσαμή Γεωργία Αναπλ. Καθηγήτρια, Δοκουμετζίδης Αριστείδης Λέκτορας
Original Title:
Υλοποίηση ενός Φυσιολογικού Φαρμακοκινητικού Μοντέλου γαστρεντερικής απορρόφησης των φαρμάκων με το υπολογιστικό πρόγραμμα SimBiology του MATLAB
Translated title:
Study of the human absorption of substances, using the program of simbiology matlab.
Summary:
In the present work the usefulness of simbiology (a program which provides the
tools of creating models using the MATLAB language) to the study of the human
absorption of two pharmaceutical substances, bicalutamide and paracetamol, was
studied.
These two substances were selected because, according to the available
literature, each one of them is classified in different classes of BCS.
Paracetamol is classified in the first class and there is no solubility
problems, while bicalutamide is classified in the second class and it presents
solubility problems.
Using the program of simbiology , pharmacokinetic models of absorption were
created for each one of the two substances. The characteristics of solubility,
distribution ,clearance and absorption of each substance were applied to the
created model in order that the amount of the human absorbed substance was
estimated. The results were studied in comparison to the results from in vivo
experiments.
The results shown that, the simbiology estimation for the two substances and
the data literature for them were relevant . This fact indicates the
usefulness of the pharmacokinetical model of absorption in the development and
the progress of pharmaceutical science.
Keywords:
Pharmacokinetic model of absorption, Bicalutamide, Paracetamol
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