Unit:
Κατεύθυνση Φαρμακευτική Ανάλυση - Έλεγχος ποιότηταςLibrary of the School of Science
Supervisors info:
Ανδρεάδου Ιωάννα Επίκ. Καθηγήτρια
Original Title:
Φαρμακολογική αξιολόγηση και προσδιορισμός επιπέδων S2O32- (ως δείκτη H2S) που απελευθερώνονται από νέους αδενινο-H2S δότες βραδείας αποδέσμευσης σχεδιασμένων ως καρδιοπροστατευτικών παραγόντων
Translated title:
Pharmacological evaluation and detection of thiosulfate levels (as biological indicator of H2S) released by novel adenine-hydrogen sulfide slow release hybrids designed as cardioprotective agents
Summary:
In the present study two new synthesised hybrid adenine-H2S donors are
pharmacologically evaluated according their ability to reduce the infract size
in animal models of ischemia-reperfusion. Afterwards, a new bioanalytical
method UPLC-UV was developped and validated to detect the plasma thiosulfate
levels, as biological indicator of H2S, that are released in vivo by the novel
donors
Keywords:
Hydrogen sulfide, Thiosulfate, Adenosine, UPLC, CMQT
Number of references:
172
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