H χρόνια επίδραση του υπεριώδους φωτός στο διαβητικό δέρμα: προστασία με φαινολικά αντιοξειδωτικά

Postgraduate Thesis uoadl:1321101 525 Read counter

Unit:
Τομέας ΦΑΡΜΑΚΕΥΤΙΚΗΣ ΤΕΧΝΟΛΟΓΙΑΣ
Library of the School of Science
Deposit date:
2011-11-16
Year:
2011
Author:
Γεωργακοπούλου Παναγιώτα
Supervisors info:
Ράλλης Μιχαήλ (Επίκουρος καθηγητής Φαρμακευτικής ΕΚΠΑ Επιβλεπων), Δάλλας Παρασκευάς (Επίκουρος καθηγητής Φαρμακευτικής ΕΚΠΑ), Δεληκωνσταντίνος Γεώργιος (Επίκουρος καθηγητής Ιατρικής ΕΚΠΑ)
Original Title:
H χρόνια επίδραση του υπεριώδους φωτός στο διαβητικό δέρμα: προστασία με φαινολικά αντιοξειδωτικά
Languages:
Greek
Summary:
Protection by antioxidant phenols
Diabetic skin is characterized by significant dry followed by possible
premature aging. The ideal damage which advance consists of an overdose of
ultraviolet light is the UV radiation which can be a precursor condition for
the appearance of skin cancer. While both diabetes and the effect of
ultraviolet light in normal skin have been studied sufficiently, however, the
relationship between diabetic skin and UV radiation is virtually unexplored.
This study investigates the relationship between diabetic skin, ultraviolet
radiation and protection capacity of natural antioxidants.
In smooth mice (male and female), after a single streptozotokin dose, it was
caused experimental diabetes type I and their skin irradiated with ultraviolet
light A and B (xenon lamp). Measurements were evaluated after a lump sum dose
of UV , a 5-day and a 14-day dose. Before, during and after irradiation,
several extracts such as: bark extract of Pinus halepensis (15%), leaves and
shoots of Rubus longanobaccus (5%) and pollen (25%), rich in phenolic
antioxidants, were implemented on mice skin.
The condition of the skin was evaluated clinically at several different periods
of time by measuring the water loss, the elasticity and the redness. Alongside,
mobility, weight and blood glucose levels of mice were assessed.
Glucose levels, after topical application and irradiation, significantly
reduced, in some cases at rates greater than 50%. The weight of the animals
showed little fluctuation and it was observed improvement in the elasticity of
their skin. It was showed, also, significant reduction of water loss when
increasing irradiation time in mice, just the opposite of what it would be
expected, as both parameters examined (diabetes, ultraviolet radiation)
exacerbate the latent water loss over time. Similar results were obtained in
the assessment of redness. Moreover, the clinical facts showed significant
protection from ultraviolet radiation in the implementation area of all
antioxidants.
In conclusion, while the UV light acts synergistically with diabetes worsening
the condition of the skin, these extracts rich in phenolic antioxidants prevent
oxidative skin damage.
Keywords:
diabetes, skin, antioxidants, UV, mice SKH-1
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
234
Number of pages:
161
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