Summary:
INFLUENCE OF CIGARETTE SMOKE AND UV LIGHT ON SKIN
- IN VIVO STUDY AND PROTECTION BY TAYBERRY EXTRACT
Inhaled cigarette smoke (CS) comes in direct contact with organs such as mouth,
lungs and stomach. Cigarette smoke in lungs has been extensively studied.
However, limited data exist on its effect on skin. Even though, it is generally
accepted that CS is among the main factors of skin aging, the number of
experimental studies showing this aging effect is very limited. It was hereby
studied the effect of twenty two days exposure to CS on the skin of hairless
mice in combination with or without ultraviolet (UV) light. In addition, it was
investigated the potential skin protection by a rich in phenolic antioxidant
compounds and ascorbic acid berry extract namely Tayberry. Male and female
hairless SKH-2 mice were exposed for 22 days to tobacco smoke and/or UV light
in vivo, and their effects on skin were investigated. Some biophysical
parameters such as development of erythema, transepidermal water loss (TEWL)
were measured. Oxidative stress was estimated by fluorescence evaluation. The
results show that UV and CS act synergistically, as shown by the enhanced TEWL,
erythema and fluorescence values. Tayberry seems to protect efficiently
of the toxic effects of CS and UV light on skin.
Keywords:
CIGARETTE SMOKE, UV LIGHT, IN VIVO, OXIDATIVE STRESS, TAYBERRY
