Unit:
Library of the School of Health SciencesLibrary of the School of Health Sciences
Supervisors info:
Καθηγητής Γεώργιος Λυρίτης
Original Title:
Διαταραχές σηματοδότησης Wnt στις καλοήθεις ινώδεις και οστικές βλάβες του κρανίου
Translated title:
Malfunctions of the wnt signal transduction pathway in the benign fibrotic and bone dysplasias of the cranial area
Summary:
The disease of benign fibrous and osseous dysplasias is a field of research with very few references, as far as their pathogenesis is concerned. Especially, the role of the Wnt signaling pathway has been much less studied. It is known that almost all diseases are the result of a complex gene regulatory network. The craniofacial dysplasias (Fibro-Osseous Lesions of the Craniofacial Complex) are a group of diseases that are most frequent in the jaws and the craniofacial bones and they are characterized by the development of fibrous tissue in the bone marrow. Their classification has been proven to be difficult, since most of them share common clinical, morphological and histopathological findings. Craniofacial dysplasias consist of a field with limited knowledge. Especially, this concerns the role of Wnt in craniofacial dysplasias. Up to date, some studies have addressed the role of Wnt/b-catenin in craniofacial dysplasias. It appeared that this signaling pathway is of extreme importance in their pathogenesis along with the NFκB and RANKL signaling pathways.
To the best of our knowledge there is not much literature dealing with the molecular mechanisms of craniofacial dysplasias, while there is extensive literature covering the clinicopathological aspects of the disease.
Yet, it appears that more studies are required in order to gain more knowledge on craniofacial diseases.
Keywords:
Fibro-osseous lesions of the craniofacial complex, Wnt signaling pathway, Fibrous dysplasia, Cherubism, Dysplasias
Number of references:
138
Number of pages:
xvii, 71
