Minimally invasive lymphadenectomy in cervical cancer

Postgraduate Thesis uoadl:1325230 534 Read counter

Unit:
Κατεύθυνση Ελάχιστα Επεμβατική Χειρουργική, Ρομποτική Χειρουργική και Τηλεχειρουργική με εξειδίκευση στη Γενική Χειρουργική
Library of the School of Health Sciences
Deposit date:
2016-12-02
Year:
2016
Author:
Rizou Anastasia
Supervisors info:
Αλέξανδρος Παπαλάμπρος, Λέκτορας Χειρουργικής, A' Χειρουργική Κλινική, Π.Γ.Ν.Α. ΛαΪκό
Χρήστος Π. Τσιγκρής, Ομότιμος Καθηγητής Χειρουργικής & Επιστημονικός Υπεύθυνος του Π.Μ.Σ.
Θεόδωρος Διαμαντής, Καθηγητής Χειρουργικής, A' Χειρουργική Κλινική, Π.Γ.Ν.Α. ΛαΪκό
Original Title:
Minimally invasive lymphadenectomy in cervical cancer
Languages:
English
Translated title:
Minimally invasive lymphadenectomy in cervical cancer
Summary:
Background
The aim of this study was to review the current literature on the role of minimally invasive
lymphadenectomy in the treatment of cervical cancer.
Methods
Non Randomized Control Trials (NRCTs) published between January 2007 to May 2016 were
identified by searching the Pubmed, EMBASE and Cochrane Library databases. Primary endpoints
included operative outcomes (operative time, intraoperative blood loss, number of transfused
patients and conversion rates), postoperative outcomes (length of postoperative hospital stay,
postoperative morbidity and postoperative in-hospital mortality), and oncologic outcomes (number
of harvested lymph nodes, tumor recurrence, disease-free rates and overall survival rates).
Results
17 studies with a total of 1676 patients were included in the review. Compared with open approach,
minimally invasive lymphadenectomy demonstrated significant larger number of harvested lymph
nodes, longer operative time, lower intraoperative blood loss and shorter postoperative hospital stay.
No significant differences were observed between the three groups for the following criteria:
lymph-node metastasis, postoperative morbidity, tumor recurrence and postoperative mortality.
Conclusion
Although a technically demanding and time-consuming procedure, minimally invasive
lymphadenectomy appears to be safe and feasible and may offer an alternative approach in staging
and treatment of cervical cancer. Multicentre randomized controlled trials investigating its long-
term oncological outcomes and its cost-effectiveness are required to determine the advantages of
this procedure over the open approach in cervical cancer.
Main subject category:
Health Sciences
Keywords:
Cervical cancer, Laparoscopy or Laparoscopic, Robot or Robotic or Da Vinci, Minimally invasive, Radical hysterectomy, Pelvic lymphadenectomy, Para-aortic lymphadenectomy
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
56
Number of pages:
27
MINIMALLY INVASIVE LYMPHADENECTOMY IN CERVICAL CANCER.pdf (1 MB) Open in new window