Τομέας Παθολογίας
Library of the School of Health Sciences

2016-12-19

2016

Geragotou Thekla

Νικόλαος Τεντολούρης, Αναπληρωτής Καθηγητής Παθολογίας, Ιατρική Σχολή, ΕΚΠΑ
Σπυρίδων Λαδάς, Καθηγητής Παθολογίας, Ιατρική Σχολή, ΕΚΠΑ
Αλέξανδρος Κόκκινος, Επίκουρος Καθηγητής Παθολογίας, Ιατρική Σχολή, ΕΚΠΑ
Δέσποινα Περρέα, Καθηγήτρια Πειραματικής Παθοβιοχημείας, Ιατρική Σχολή, ΕΚΠΑ
Πέτρος Σφηκάκης, Καθηγητής Παθολογίας, Ιατρική Σχολή, ΕΚΠΑ
Κωνσταντίνος Μακρυλάκης, Αναπληρωτής Καθηγητής Παθολογίας, Ιατρική Σχολή, ΕΚΠΑ
Αναστασία Θανοπούλου, Επίκουρη Καθηγήτρια Β' Παθολογικής Κλινικής Πανεπιστημίου Αθηνών, ΕΚΠΑ

Η σχέση του μεταβολικού συνδρόμου με τη λειτουργία των β-κυττάρων και την ευαισθησία στην ινσουλίνη

Greek

Background. There are different metabolic syndrome traits among patients with
different ethnicities. Methods. We investigated this by studying 44 South Asians and
54 Europeans and classified them in three groups according to the occurrence of
metabolic syndrome (MetS) and Type 2 Diabetes (T2D). Insulin sensitivity index
(ISI), static, dynamic and total beta-cell responsivity indices (Φ), and disposition
indices (DI) were calculated with the use of oral minimal model (OMM). Results. In
both ethnicities, ISI was lower in the subgroup with MetS and T2D as compared to
the subgroup without MetS neither T2D (P <0.004). South Asians without MetS were
more insulin resistant than Europeans without MetS (P = 0.033). In the South Asians,
ISI, dynamic DI and static DI were associated significantly (P <0.006) with highdensity
lipoprotein cholesterol and triglycerides. In the Europeans, ISI was associated
with waist-to-hip ratio (P = 0.005) and systolic and diastolic blood pressure
(P<0.005), while static DI was related to the systolic blood pressure (P = 0.005).
Conclusions. MetS was linked with insulin resistance and reduced capacity to handle
glucose regardless of ethnicity. ISI and DIs were associated with lipid traits in South
Asians and with blood pressure in Europeans suggesting that insulin resistance
enhances different metabolic syndrome traits among different ethnicities.

Health Sciences

Metabolic syndrome, South Asians, Diabetes type 2, oral minimal model

No

0

Yes

433

196

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https://pergamos.lib.uoa.gr/uoa/dl/object/1326216