Τομέας Χειρουργικής
Library of the School of Health Sciences

2017-01-11

2016

Oikonomidis Nikolaos

Δέσποινα Περρέα, Καθηγήτρια, Ιατρική, ΕΚΠΑ
Ιωάννης Ρίζος, Καθηγητής, Ιατρική, ΕΚΠΑ
Νικόλαος Νικητέας, Καθηγητής, Ιατρική, ΕΚΠΑ
Κωνσταντίνος Κοντζόγλου, Αναπληρωτής Καθηγητής, Ιατρική, ΕΚΠΑ
Χρήστος Βερύκοκος, Επίκουρος Καθηγητής, Ιατρική, ΕΚΠΑ
Δημήτριος Δημητρούλης, Επίκουρος Καθηγητής, Ιατρική, ΕΚΠΑ
Ευάγγελος Μισιακός, Αναπληρωτής Καθηγητής, Ιατρική, ΕΚΠΑ

Μελέτη της φλεγμονής, της ιστικής και ανοσολογικής αντίδρασης σε πρώιμα στάδια αθηρωμάτωσης

Greek

The present study aims to investigate the potential preventive antiatherosclerotic activities of simvastatin in rabbits that receive a pre-treatment with simvastatin and afterwards they turn to an atherogenic diet. Twenty two male New Zealand rabbits were studied. Control group (C); the cholesterol group A rabbits were fed a commercial rabbit chow supplemented with 0.5% w/w cholesterol for 8 weeks and then fed with normal chow for additional 8 weeks; The group B rabbits received initially standard commercial rabbit chow along with simvastatin administration for 8 weeks and afterwards they followed the high cholesterol diet for another 8 weeks. The animals receiving simvastatin as pre-treatment presented significantly lower serum cholesterol and LDL cholesterol levels when compared to the non simvastatin treated cholesterol fed animals. In parallel, none animal in simvastatin group presented atherosclerotic lesions in the aorta. Simvastatin exhibits preventive properties against the formation of atherosclerosis in our atherosclerosis model, through mainly its hypolipidemic role.

Φλεγμονή, Ανοσολογική αντίδραση, Αθηρωμάτωση

No

0

Yes

297

115

File access is restricted only to the intranet of UoA.

https://pergamos.lib.uoa.gr/uoa/dl/object/1326556