Unit:
Κατεύθυνση Περιβάλλον και Υγεία: Διαχείριση Περιβαλλοντικών Θεμάτων με Επιπτώσεις στην ΥγείαLibrary of the School of Health Sciences
Supervisors info:
Ευαγγελία Πρωτόπαπα Καθηγήτρια, Σχολή Επαγγελμάτων Υγείας & Πρόνοιας, Α.Τ.Ε.Ι Αθήνας
Πολυξένη Νικολοπούλου-Σταμάτη, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Ανδρέας Λάζαρης, Αν. Καθηγητής,Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Φωτοχημικές βλάβες του DNA και η επίδραση τους στην υγεία του δέρματος
Translated title:
Tha photochemical damage of DNA and its effects on thw skin health
Summary:
The frequent appearance of the skin cancer constantly increasing in recent years, is fact, and is related with an increased frequency exposure to the sunlight. The sun is essential for the human body, however the overexposure has negative consequences. The skin has all the mechanisms in order to be protected by the sunlight, but sometimes these are not enough.
Ozone depletion due to the air pollution, has consequence that the ultraviolet radiation that reaches the earth's surface not to be filtered and cause photochemical damages to DNA. The result of this specific procedure is the formulation of photoproducts (mainly bilateral cyclobutane, compounds of 6-4 pyrimidine –pyrimidone). The presence of these products cause changes in the functioning of skin cells resulting in an acute event and chronic damage to the skin. Additional factors contributing to the occurrence of cancer in the skin, are genetic factors (heredity) pre-disposing skin disorders, chemical carcinogens, oncogenes - suppressor genes (p 53 gene).
Continuously a lot of research are studying the relationship between the appearance of skin cancers and the overexposure the UV radiation, in order to inform and to sensitize the population. Unfortunately, the awareness of a large part of the population in this specific subject is small, while few of them have the intention to change their lifestyle in this specific thesis.
Main subject category:
Health Sciences
Keywords:
Photoageing, Skin cancer, Ultraviolet Radiation
File:
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Zika Aikaterini MSc.pdf
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File access is restricted only to the intranet of UoA.
