Breast cancer and thyroid hormone.

Doctoral Dissertation uoadl:1329437 316 Read counter

Unit:
Τομέας Βασικών Επιστημών
Library of the School of Health Sciences
Deposit date:
2017-02-24
Year:
2009
Author:
Armonis Basil
Dissertation committee:
Παπαβασιλείου Αθανάσιος, Καθηγητής, Ιατρική, ΕΚΠΑ
Ζωγράφος Γεώργιος, Καθηγητής, Ιατρική, ΕΚΠΑ
Πάντος Κωνσταντίνος, Αναπληρωτής Καθηγητής, Ιατρική, ΕΚΠΑ
Τυλιγάδα Αικατερίνη, Αναπληρώτρια Καθηγήτρια, Ιατρική, ΕΚΠΑ
Κουλουλίας Βασίλειος, Αναπληρωτής Καθηγητής, Ιατρική, ΕΚΠΑ
Τραφαλής Δημήτριος, Επίκουρος Καθηγητής, Ιατρική, ΕΚΠΑ
Μουρύζης Ιορδάνης, Επίκουρος Καθηγητής, Ιατρική, ΕΚΠΑ
Original Title:
Καρκίνος του μαστού και θυρεοειδική ορμόνη.
Languages:
Greek
Translated title:
Breast cancer and thyroid hormone.
Summary:
Objective. Recent evidence shows that Thyroid Hormone signaling is altered in stressed cells due to its interaction to growth kinase signaling with important physiologic consequences. Thus, we investigated whether thyroid hormone levels are correlated to cell proliferation (Ki67), in euthyroid patients with breast cancer.

Design and Methods. In this study were included 86 newly diagnosed breast cancer patients with estrogen receptor positive [ER(+)] tumors, who were referred for surgery.

Results. FT3, FT4, and TSH were within normal range. No correlation was seen between Ki67 and FT3 (r = −0.17, p= 0.15), FT4 (r = −0.13, p= 0.25), or TSH (r = −0.10, p= 0.39) in all patients studied. However, subgroup analysis showed that, in HER2(+) patients, a negative correlation has been observed between FT3 levels and Ki67 (r = −0.60 and p= 0.004) but not between Ki67 and FT4 (r = 0.04 and p= 0.85) or TSH (r = −0.23 and p= 0.30). In HER2(−) patients, there was no significant correlation between Ki67 and FT3 (r = −0.06, p= 0.67), FT4 (r = −0.15, p= 0.26), or TSH (r = −0.09, p= 0.49). Phospho-p44/total-p44 ERK levels were found to be increased 2-fold in HER2(+) versus HER2(−) tumors. No difference was detected in phospho-p42/total p42 ERK levels.

Conclusion. Thyroid Hormone profile is not altered in patients with newly diagnosed breast cancer and because of it. However, FT3 levels, even within normal range, were negatively correlated with cell proliferation in the HER2(+) breast cancer tumors of this study. This response may be due to the interaction between ERK and Thyroid Hormone signaling.
Main subject category:
Health Sciences
Keywords:
Breast cancer, Thyroid hormone
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
108
Number of pages:
87
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