Synthesis of acylated derivatives of 3-aminophthalhydrazide as compounds with potential biological applications

Postgraduate Thesis uoadl:1363443 434 Read counter

Unit:
Κατεύθυνση Οργανική Σύνθεση και Εφαρμογές της στη Χημική Βιομηχανία
Library of the School of Science
Deposit date:
2017-03-17
Year:
2017
Author:
Daskalaki Despoina-Ira
Supervisors info:
Γεώργιος Χ. Βουγιουκαλάκης, Επίκουρος Καθηγητής
Original Title:
Σύνθεση ακυλιωμένων παραγώγων του 3-αμινοφθαλυδραζιδίου ως ενώσεις με πιθανές βιολογικές εφαρμογές
Languages:
Greek
Translated title:
Synthesis of acylated derivatives of 3-aminophthalhydrazide as compounds with potential biological applications
Summary:
Heterocyclic nitrogen compounds have been studied extensively due to their numerous applications in various sectors with more important those of biology and medicine. In particular, a large number of research works have synthesized and evaluated the biological activity of oxygenated derivatives of phthalazine, phthalazine and phthalhydrazide, which are now widely used as therapeutic agents, due to their multiple action as antiviral, analgesic, anti-inflammatory and anti-cancer drugs. An important feature of phthalhydrazide is its chemiluminescent emission under speficic oxidative conditions. Derivatives of these cyclic hydrazides have been used in analytical and biochemical applications, but also in promissing sectors such as photodynamic and targeted therapy. The combination of these compounds with other functional groups, by acylation, alkylation and aromatic substitution, is a real challenge, as it can lead to the synthesis of novel compounds with unique physicochemical and biological nature.In the present thesis,derivatives of phthalazine with possible biological activity have been synthesized. An appropriate methodology for preparing them has been developed, while all intermediates and final products were characterized by nuclear magnetic resonance (1H and 13C NMR) and mass spectrometry. The synthesis of these derivatives focuses on acylation and thioacylation reactions of the amino group of a phthalazine derivative and the precursor molecule, a phthalimide with lipophilic ions, such as triphenylphosphine cationic derivatives, in order to investigate their chemiluminescent and possible photobiological action.
Main subject category:
Science
Keywords:
Phthalhydrazide, acylation, biological activity, chemiluminescence.
Index:
Yes
Number of index pages:
8
Contains images:
Yes
Number of references:
136
Number of pages:
140
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