Unit:
ΠΜΣ Καρδιοαναπνευστική ΑναζωογόνησηLibrary of the School of Health Sciences
Author:
Tampakis Konstantinos
Supervisors info:
Σιαφάκα Ιωάννα, Καθηγήτρια, Ιατρική, ΕΚΠΑ
Ιακωβίδου Νικολέττα, Καθηγήτρια, Ιατρική, ΕΚΠΑ
Ξάνθος Θεόδωρος, Καθηγητής, Ιατρική, ΕΚΠΑ
Original Title:
Ο ρόλος της χορήγησης λιπιδίων στην ανακοπή
Translated title:
Lipid emulsion therapy: a review of the literature
Summary:
Intravenous lipid emulsions (ILE) were developed many decades ago to supply nutritional requirements to patients unable to obtain adequate enteral gestation.The utility of ILE was extended to therapeutics, facilitating the delivery of drugs. More recently, the potential for ILE to act as an antidote for inversion of drug toxicity has been recognized. Mainly used for local anesthetics toxicity, ILE therapy has been expanded in clinical toxicology involving overdose treatment of drugs other than local anesthetics. Partitioning in a lipid phase of fat droplets, a mechanism named lipid sink phenomenon, has primarily been described to explain this action of ILE and remains the most widely accepted while recent research has also revealed several molecular mechanisms that may contribute to ILE efficacy. Due to lack of randomized clinical trials, recommendations on administration are based on animal studies and published cases. Thus, the constantly increased knowledge about ILE therapy supports the need for detailed appraisal. The aim of this review is to summarize the previous and current literature on ILE therapy. Suggested mechanisms of action, safety profile and recommendations on administration of ILE in cases of drug intoxication are highlighted.
Main subject category:
Health Sciences
Keywords:
Lipid emulsion, Cardiac arrest, Drug toxicity, Cardiopulmonary resuscitation, Drug poisoning
Number of references:
100
