Κατεύθυνση Κλινική Βιοχημεία - Μοριακή Διαγνωστική
Library of the School of Science

2017-05-11

2017

Panagiotopoulou Evgenia-Maria

Σταματάκης Αντώνιος, Aναπληρωτής Βιολογίας-Βιολογία Συμπεριφοράς, Νοσηλευτική, ΕΚΠΑ

ΠΡΟΣΔΙΟΡΙΣΜΟΣ ΕΠΙΠΕΔΩΝ ΤΟΥ ΥΠΟΔΟΧΕΑ ΤΗΣ ΣΕΡΟΤΟΝΙΝΗΣ ΤΥΠΟΥ 2Α ΣΤΟΝ ΕΓΚΕΦΑΛΟ ΕΠΙΜΥ

Greek

Determination of the levels of serotonin 2a receptor in the rat brain

Exposure of an organism to stressful situations, particularly neonatal experiences, affect the development and function of many areas of the brain that are involved in the regulation of the hypothalamic-pituitary-adrenal axis. To study the interactions of genes and the environment, animal models involving rodent experiments are widely used. The maternal-neonatal relationship plays a crucial role in the studies, because at first they develop communication skills and in the second time their interaction helps to reduce stress while also regulating the emotional factor, which has an impact on adult life. The involvement of serotonergic function causes long-term effects when the body is exposed to early stressful stimuli. At the same time, epigenetic modifications that come from environmental stimuli can affect gene expression and damage the body.

Health Sciences

Early experiences, serotonin, serotonin 2a receptor, epigenetic modifications, 5-HT2A immunohistochemistry, methylation levels of the HTR2A gene promoter

Yes

5

Yes

12

94

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https://pergamos.lib.uoa.gr/uoa/dl/object/1511444