ΠΜΣ Επεμβατική Ακτινολογία
Library of the School of Health Sciences

2017-05-19

2017

Kiakidis Theodoros

Αικατερίνη Μαλαγάρη, Αναπληρώτρια καθηγήτρια Ακτινολογίας, Ιατρική, ΕΚΠΑ
Αχιλλέας Χατζηιωάννου, Καθηγητής Ακτινολογίας, Ιατρική , ΕΚΠΑ
Ευθυμία Αλεξοπούλου , Αναπληρώτρια Καθηγήτρια Ακτινολογίας ,Ιατρική, Ε.Κ.Π.Α

Φαρμακοκινητική χημειοεμβολισμού με σφαιρίδια που εκλύουν χημειοθεραπευτικά. Μελέτη σε ΗΚΚ

Greek

Goal of the study
The study examines the safety, the efficacy an the pharmacokinetics of
chemoembolization with loaded microspheres smaller than 100 μm in
hepatocellular carcinoma
Materials and methods
In this study chemoembolization was performed with doxorubicin
loaded microspheres initially at 19 patients and afterwards at 52 with
escalation of size( of the tumor,as well as of thespheres) and dose 150 or 10 mg of doxorubicin). The study is continued.
Results
The mean diameter of the tumors was 7.28±2.09 cm (range 4-12 ) and
the primary/multiple distribution was 51.9%/48.1%. Twenty five patients
were the low dose group and twenty seven the B group of high dose.
Three patients of the high dose group presented biliary damage. The
mean of maximum concentration of doxorubicin in the plasma Cmax±SD
was 284.9±276.2 ng/mL for high dose and 108.5±77.6 ng/mL for low
dose of loading (p<0.001). According to the mRECIST criteria ,the overall
objective response after two sessions reached 61.22% and 63.82% in six
months respectively. It must be noted that after the second session total
response of the targeted tumor was 28.57% and was maintained at
23.40% in six months.
The local response percentages showed no statistical significance
between the high and low dose loading groups.
The overall survival (OS) in 6 months , 1 , 2 years was 98.08 , 92.3 and
88.46 respectively .The overall survival and the progression free survival showed no statistically important differences between the two groups
Conclusion
a) The microspheres with diameter smaller than 100 μm can achieve
high percentages/levels of local response and midterm survival
b) The high loading of the microspheres with the drug, not only doesn’t have clinical benefits ( no greater tumor necrosis ) but is also related with higher toxicity of the biliary tree (biliary dilatation). The high loading causes a great and quick release o the chemotherapeutic in
the ionic environment of the blood flow, especially when we use the
spheres with smaller diameter . As a consequence the small spheres
must not be loaded with high dose of doxorubicin c) The smaller spheres lead to longer survival
d) More patients are required for further conclusions [besides the
ones] that have been included in the reference publication/report

Health Sciences

Pharmacokinetics, Doxoroubicin, Embolic spheres, Chemoembolization, Hepatocellular Carcinoma, HCC

No

0

Yes

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https://pergamos.lib.uoa.gr/uoa/dl/object/1519027