Study of the genetic profile of the pancreatic neuroendocrine tumors

Doctoral Dissertation uoadl:1668285 491 Read counter

Unit:
Faculty of Medicine
Library of the School of Health Sciences
Deposit date:
2017-06-19
Year:
2017
Author:
Karakaxas Dimitrios
Dissertation committee:
1.Αναστάσιος Μαχαίρας- Καθηγητής, Ιατρική, ΕΚΠΑ
2.Θεόδωρος-Κων/νος Λιακάκος- Καθηγητής, Ιατρική, ΕΚΠΑ
3.Μαρία Κυριακοπούλου-Λυμπέρη- Καθηγήτρια, Ιατρική, ΕΚΠΑ
4.Μαρία Γαζούλη- Αναπληρώτρια Καθηγήτρια, Ιατρική, ΕΚΠΑ
5.Παύλος Πατάπης- Αναπληρωτής Καθηγητής, Ιατρική, ΕΚΠΑ
6.Γεώργιος Καραμανώλης- Επίκουρος Καθηγητής, Ιατρική, ΕΚΠΑ
7.Ανδρέας Αλεξάνδρου- Επίκουρος Καθηγητής, Ιατρική, ΕΚΠΑ
Original Title:
Μελέτη του γενετικού υποβάθρου των νευροενδοκρινικών νεοπλασιών του παγκρέατος
Languages:
Greek
Translated title:
Study of the genetic profile of the pancreatic neuroendocrine tumors
Summary:
Pancreatic neuroendocrine tumors share a unique genetic identity, functional behavior, and clinical course. Untreated tumors have a high possibility to grow locally into adjacent structures or spread to distant organs. Although surgical excision, irrespective of tumor functioning or nonfunctioning state, remains the cornerstone of therapy, providing the best disease-free and survival rates to date, the understanding of the genetic nature of the disease yields new ‘targets’ to consider in drug development.
Gastroenteropancreatic neuroendocrine tumors (NETs) express different cytokines and growth factors, and the increased frequency of occurrence in the setting of inflammatory bowel disease led to the assumption that chronic inflammation might play a role in the NETs development and that a number of more predominant low penetrance genes contribute to gastroenteropancreatic NETs susceptibility.
In this study polymorphisms of the TNF-α and IL-1β genes were analyzed regarding their role in the promotion of pancreatic neuroendocrine tumors.
Main subject category:
Medicine
Keywords:
pancreas, neuroendocrine tumors, TNF-a, IL-1b, single nucleotide polymorphisms
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
187
Number of pages:
152
Μελέτη του γενετικού υποβάθρου των νευροενδοκρινικών νεοπλασιών του παγκρέατος.pdf (19 MB) Open in new window