Unit:
Κατεύθυνση Κοσμητολογία - ΔερματοφαρμακολογίαLibrary of the School of Science
Supervisors info:
Χατζηιωάννου Αργυρώ, Αναπληρώτρια Καθηγήτρια Α΄ Πανεπιστημιακή Κλινική
Αφροδίσιων και Δερματικών Νόσων, Νοσοκομείο Α. Συγγρός
Δάλλας Παρασκευάς, Επίκουρος Καθηγητής Τομέα Φαρμακευτικής Τεχνολογίας,
Τμήμα Φαρμακευτικής, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Ράλλης Μιχαήλ, Επίκουρος Καθηγητής Τομέα Φαρμακευτικής Τεχνολογίας, Τμήμα
Φαρμακευτικής, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Original Title:
Καρκινογένεση Διαβητικού Δέρματος
Translated title:
Cancer in Diabetic Skin
Summary:
Diabetic mellitus induces many pathophysiological changes in skin. The effect
of UV light on chronic exposure in diabetic and normal skin was investigated.
Hairless mice skin, diabetic (D) and non-diabetic (ND), were exposed to UVA
and UVB radiation 3 times per week for 32 weeks. The irradiation dose was equal to
0.75 M.E.D during the first week and increased by 25% each week until the maximal
dose was 3.5 M.E.D. Diabetes was induced by streptozotocin injection. Stratum
corneum hydration of D mice was significantly lower than ND (p<0.01). The
transepidermal water loss of D mice was less than ND mice due to the dryness of the
skin of D mice. The elasticity of ND mice's skin was significantly higher (p<0.05). Skin
sebum in the D mice was much lower in relation to ND (p<0.05). Skin of D mice is
more pigmented and thinner than this of ND. Hydrophilic antioxidants (glutathione
and uric acid) in SC were evaluated, glutathione and uric acid were lower in D.
Oxidative stress (in SC) and histopathologically tests of D and ND mice are in process
of evaluation.
These results suggest that D mice presented more severe inflammation and
photoageing after chronic UV irradiation, but only ND mice have non melanoma skin
cancer (SCC).
Main subject category:
Science
Other subject categories:
Pathologic conditions, signs and symptoms
Keywords:
squamous cell carcinoma, diabetic skin, ultraviolet radiation, oxidative stress
Number of references:
108
