Κατεύθυνση Κοσμητολογία - Δερματοφαρμακολογία
Library of the School of Science

2017-07-07

2017

Karasmani Marina

Δάλλας Παρασκευάς, Επίκουρος Καθηγητής Τομέα Φαρμακευτικής Τεχνολογίας, Τμήμα Φαρμακευτικής, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Ράλλης Μιχαήλ, Επίκουρος Καθηγητής Τομέα Φαρμακευτικής Τεχνολογίας, Τμήμα
Φαρμακευτικής, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Σκαλτσά Ελένη, Καθηγήτρια Τομέα Φαρμακογνωσίας και Χημείας Φυσικών
Προϊόντων, Τμήμα Φαρμακευτικής, Εθνικό και Καποδιστριακό Πανεπιστήμιο
Αθηνών

Επίδραση του σαλικυλικού, γαλακτικού, ρετινοϊκού οξέος και του επιδερμικού αυξητικού παράγοντα στην αντιμετώπιση της φωτογήρανσης

Greek

The effect of salicylic, lactic, retinoic acid and epidermal growth factor in the treatment of photoaging

Photoaging of the skin is a phenomenon caused by the cumulative effect of the UV Radiation. Free radical species caused by UV Radiation cause gradual breakdown of the connective tissue components such as collagen and elastin, leading to the clinical signs of photodamage skin.
The most known topical therapies for the treatment of photoaging are the retinoids, hydroxyacids and growth factors. Even though, the effect of retinoids and hydroxyacids has been extensively studied, the effect of epidermal growth factor is still unexplored.
In this study, two experiments were conducted. In the first one, the effect of epidermal growth factor on the prevention and treatment of photoaging was evaluated. While in the second one this effect was compared with that of retinoic, lactic and salicylic acid. Finally, we measured the antioxidant capacity of the skin in each group.
40 hairless SKH-2 mice were irradiated with increasing UVR doses (0.33-1 MED) and their skins were evaluated after topical application of the epidermal frowth factor. At the second experiment, 50 SKH-2 mice were irradiated with increasing UVR doses (0.5-2 MED) and the skin and antioxidants of the mice were evaluated after topical applications of tretinoin, lactic acid, salicylic acid and epidermal growth factor.
The results indicate that the topical applications of tretinoin and epidermal growth factor enhances the restoration of skin elasticity. Furthermore, the antioxidant defense of the mice was the lowest in salicylic acid group. Additional studies are needed to investigate the more effective treatment of photoaging and its combination with the antioxidant protection of the skin.

Science

Pharmacy

Skin – Photoaging – Epidermal growth factor

Yes

5

Yes

86

149

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https://pergamos.lib.uoa.gr/uoa/dl/object/1708728