The interplay between galectin-3 and neutrophil gelatinase-associated lipocalin in patients with systolic heart failure.

Postgraduate Thesis uoadl:1708780 532 Read counter

Unit:
ΠΜΣ Καρδιοαναπνευστική Αναζωογόνηση
Library of the School of Health Sciences
Deposit date:
2017-07-07
Year:
2017
Author:
Tsalamandris Sotirios
Supervisors info:
Δημήτρης Τούσουλης, Καθηγητής, Ιατρική, ΕΚΠΑ
Εμμανουήλ Βαβουρανάκης, Αναπλ. Καθηγητής, Ιατρική, ΕΚΠΑ
Ευαγγελία Κουσκούνη, Καθηγήτρια, Ιατρική, ΕΚΠΑ
Original Title:
Μελέτη της σχέσης των επιπέδων της galectin-3 με τη νεφρική λειτουργία και τα επίπεδα της neutrophil gelatinase-associated lipocalin σε ασθενείς με καρδιακή ανεπάρκεια.
Languages:
Greek
Translated title:
The interplay between galectin-3 and neutrophil gelatinase-associated lipocalin in patients with systolic heart failure.
Summary:
Background: Renal function may be impaired in heart failure (HF) patients. Neutrophil Gelatinase-Associated Lipocalin (NGAL) is a biomarker of renal injury associated with the progression of the disease.
Objectives: To examine the association of renal injury with Galectin-3, a mediator of myocardial fibrosis and remodeling, in patients with chronic HF.
Methods: We consecutive enrolled 115 subjects with stable ischemic HF with reduce ejection fraction. Serum levels of Galectin-3, b-type natriuretic peptide (BNP), NGAL and tumor necrosis factor alpha (TNFa) were measured. Creatinine clearance (CrCl) was estimated using Cockcroft-Gault formula.
Results: NGAL levels were positive correlated with Galectin-3 levels (rho=0.26, p=0.04), with BNP levels (rho=0.30, p=0.005), with TNF-a levels (rho=0.24, p=0.01) and inversely correlated with left ventricle ejection fraction (rho=-0.31, p=0.02). NGAL levels were also positively correlated with Creatinine levels and inversely associated with CrCl. After adjustment for many confounders including age, gender, diabetes mellitus, hypertension, CrCl and BNP; NGAL was independently associated with Galectin-3 levels.
Conclusions: In the present study we found a positive correlation between NGAL and Galectin-3 in patients with heart failure. These findings reveal the potential association between renal injury and myocardial fibrosis and remodeling in heart failure and highlight the importance of renal function monitoring in patients with HF.
Main subject category:
Health Sciences
Keywords:
Heart failure, Renal function, Biomarkers, Fibrosis, Galectin 3, Neutrophil gelatinase-accociated lipocalin.
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
197
Number of pages:
108
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