Unit:
Κατεύθυνση Κοσμητολογία - ΔερματοφαρμακολογίαLibrary of the School of Science
Author:
Grigoropoulos Andreas
Supervisors info:
Ράλλης Μιχαήλ, Επίκουρος Καθηγητής, Τομέα Φαρμακευτικής Τεχνολογίας, Τμήμα Φαρμακευτικής, Σχολή Επιστημών Υγείας, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Original Title:
Κλινική Συγκριτική Μελέτη Επουλώσεως Χρόνιων Ελκών με Ελαϊκό Εκχύλισμα του Ισοπόδου Ceratothoa oestroides
Translated title:
Clinical evaluation of wound healing capacity of isopod Ceratothoa oestroides oil extract
Summary:
Chronic ulcers are an important health issue that affects a large part of the population. It is estimated that 1 to 2% of the population of developed countries will experience a chronic ulcer in their lifetime. As life expectancy increases, the number of patients with chronic ulcers increase as well, due to the fact that the rate of healing slows down significantly over time. Complications of chronic ulcers include infection, often mutilation, poor quality of life and may lead to impotence, disability, even death.
Some strong preclinical evidence of pharmacological and toxicological studies about isopod Ceratothoa oestroides oil extract, which took place in Small Animal Laboratory in the Department of Pharmaceutical Technology of National and Kapodistrian University of Athens, leads us to design a randomized, double-blinded, parallel group, clinical study, which was conducted in the Ulcers Unit of Andreas Syggros Hospital of Cutaneous & Venereal Diseases.
Twenty-five patients, with a venous or metabolic ulcer, who met the inclusion criteria were randomized to receive daily dressing with either ointment containing isopod oil extract, gentamicin, polymyxin B and acetic acid (13 patients) or a well-known and widely used in the clinical practice healing cream consisting of sodium hyaluronate and silver sulfadiazine (12 patients).
Every two weeks, the healing progress and the safety were evaluated clinically and by some measurements like wound area measurement, Bates Jensen and PUSH score, percent of wound healing, exudate amount etc. A defined endpoint was either a completed healing of the wound or healing progress 14 weeks after recruitment. In case of completed healing, measurements of transepidermal water loss and hydration took place to evaluate the quality of it.
The analyze of the results showed a clear indication of a greater wound healing effect of isopod oil extract ointment in comparison of the widely used healing cream. Due to the fact that the sample size was small, statistically significance was not reached over all the results.
Main subject category:
Science
Other subject categories:
Pharmaceutical technology
Keywords:
wound healing, clinical evaluation, chronic ulcers, Ceratothoa oestroides
Number of references:
172
File:
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Διπλωματική Εργασία (Επιδιορθωμένο).pdf
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