Prognostic significance of EGFR and COX-2 expression in colorectal cancer and their association. A study in Greek population.

Doctoral Dissertation uoadl:1713612 792 Read counter

Unit:
Τομέας Κλινικοεργαστηριακός
Library of the School of Health Sciences
Deposit date:
2017-07-12
Year:
2017
Author:
Mouzakiti Anna
Dissertation committee:
Γεννατας Κωνσταντινος Καθηγητης , Ιατρική, ΕΚΠΑ
Βωρος Διονυσιος Καθηγητης , Ιατρική, ΕΚΠΑ
Βλαχοδημητροπουλος Δημητριος, Αναπληρωτης καθηγητη , Ιατρική, ΕΚΠΑ
Γούτας Νικόλαος ,Αναπληρωτής Καθηγητής , Ιατρική, ΕΚΠΑ
Κόντης Ιωάννης, Αναπληρωτής Καθηγητής , Ιατρική, ΕΚΠΑ
Σμυρνιώτης Βασίλειος, Καθηγητής , Ιατρική, ΕΚΠΑ
Φράγκου-Πλεμένου Ματρώνα, Επίκουρη Καθηγήτρια , Ιατρική, ΕΚΠΑ
Original Title:
Η προγνωστική σημασία της έκφρασης του επιδερμικού αυξητικού παράγοντα (EGFR)και της κυκλοοξυγενάσης -2 (COX2)στον καρκίνο του παχέος εντέρου και ο συσχετισμός τους με κλινικές και ιστολογικές παραμέτρους
Languages:
Greek
Translated title:
Prognostic significance of EGFR and COX-2 expression in colorectal cancer and their
association. A study in Greek population.
Summary:
Introduction: Colon cancer is one of the most common malignancies. Various
prognostic markers have been proposed and individualized treatment strategies have
been adapted according to tumor molecular and genetic characteristics. The aim of the
present study is to retrospectively analyze a possible association between the
expression of COX-2 and EGFR and clinical and histopathological factors of patients
undergoing colon surgery in our department in the Greek population.
Methods: Data from our department's prospectively collected database were retrieved
for a total of 100 consecutive colectomies that were performed in our department. We
examined patient age, sex, tumor stage and location of the tumor. Histological data
were also retrieved concerning major tumor diameter, histological grade and
immunohistochemical expression of COX-2 and EGFR.
Results: There was no difference between tumors of different differentiation in the
expression of EGFR (p=0.146), while there was statistically significant difference in the
expression of COX-2 between these groups (p=0.001). There was no difference
between these patients in the expression of EGFR (p=0.136), while a statistically
significant difference was found in the expression of COX-2 between the same patient
groups (p<0.005).
Conclusions: This is a study of COX-2 and EGFR expression pattern and association
with clinical and histopathology factors in a Greek population of colorectal cancer
patients. These data are quite important in order to certify that colorectal cancer
molecular and genetic diversity between different study populations is not a
confounding factor in the application and clinical implementation of trending
individualized decision making in oncological treatments.
Main subject category:
Health Sciences
Keywords:
Epidermal growth factor,Cicloxigenasi2, Colon cancer, Prognostic factor
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
81
Number of pages:
100
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