Κατεύθυνση Παιδοδοντιατρική (Κλινικές Ειδικεύσεις)
Βιβλιοθήκη Οδοντιατρικής

2017-07-12

2017

Babatzia Anastasia

Σωτηρία Γκιζάνη, Επίκουρη Καθηγήτρια Παιδοδοντιατρικής,Οδοντιατρική Σχολή, ΕΚΠΑ
Βασίλειος Παπαϊωάννου, Επίκουρος Καθηγητής Κοινωνικής και Προληπτικής Οδοντιατρικής, Οδοντιατρική Σχολή, ΕΚΠΑ
Χριστίνα Κανακά - Gantenbein, Καθηγήτρια Παιδιατρικής Ενδοκρινολογίας-Νεανικού Διαβήτη στην Α’ Παιδιατρική Κλινική της Ιατρικής Σχολής του Πανεπιστημίου Αθηνών στο Νοσοκομείο Παίδων “Η Αγία Σοφία”

Στοματική υγεία και ανάπτυξη στελεχών του μύκητα Candida albicans στη στοματική κοιλότητα παιδιών και εφήβων με Σακχαρώδη Διαβήτη τύπου 1 σε σύγκριση με αντίστοιχα υγιή άτομα

Greek

Oral health status and oral Candida albicans in children and adolescents with Diabetes Mellitus type 1 and comparison with healthy subjects

Background: Diabetes mellitus (DM) is a group of metabolic diseases that can affect the oral health status, especially when it is not controlled.
Aim: The aim of the study was to determine the oral health and oral Candida albicans of children and adolescents with controlled and uncontrolled diabetes type 1 (T1D) and to compare them with a similar group of healthy ones.
Design: One hundred forty-four (144) children-adolescents (6 to15 years) were allocated in three groups: (a) 35 with poorly - glycemic controlled diabetes (PGC, HbA1c<7.5%), (b) 39 with good – glycemic controlled diabetes (GGC, HbA1c≥7.5%) and (c) 70 healthy. The children with diabetes were out-patients of the children´s hospital «Agia Sophia». Plaque index (PlI) (Silness & Loe 1964), gingival index (GI) (Silness & Loe 1964), calculus index (Greene & Vermillion 1960, 1964) and DMFS index, for caries, were used. Flow rate and buffer capacity were estimated using the CRT test by Ivoclar-Vivadent. Stimulated saliva was transferred and prepared for DNA extraction for the detection and identification of oral Candida albicans and Streptococcus mutans with real time PCR technique. The examinations were performed by two calibrated examiners (κ>0.8). Median regression was implemented to assess potential associations between clinical characteristics (PlI, GI, CI, DMFS) of diabetes groups and control group. Microbial counts were log transformed. All analyses were conducted using Stata 14.1 (StataCorp, College Station, USA). The level of significance was set at 0.05.
Results: Differences in the PlI levels among the three groups were significantly different. Statistical analysis showed that PlI levels of the poorly-glycemic controlled individuals were significantly different from the control children (p=0.034). The GI and calculus, however were not significantly different among the three groups (p > 0.05). Mean DMFS was determined to be 3.09 for the poorly-glycemic controlled group, 1.18 for the good-glycemic controlled and 1.48 for the healthy. Difference among the groups were not statistically significant (p > 0.05). In all children, a normal flow rate and a high buffering capacity were recorded. C. albicans was found in 13 out of 35 PGC diabetic children, 9 of 39 GGC diabetic and 13 out of 70 healthy controls. The mean values of C. albicans were: 3.01 log cfu/ml (SD= 0.94) in the PGC diabetic children, 2.87 (SD= 0.92) in the GGC diabetics and 3.13 (SD= 1.19) in the healthy controls (p > 0.05). S. mutans was isolated from the oral cavity of 96 of the 144 individuals. A statistically significant difference in the levels of S. mutans was found between the PGC diabetes group and GGC (p=0.032). S. mutans was detected in 75% of children with type 1 diabetes.
Conclusions: The results suggest that children with type-1 diabetes have poorer oral hygiene and are at higher risk to develop dental caries, especially when their medical condition is uncontrolled. Greater efforts are required to improve oral hygiene of these patients and prevent complications. Future research should be carried out in order to better investigate the association of glycemic control over the years with the oral health and microbial status.

Health Sciences

Dentistry

children, oral health status, Candida albicans, Streptococcus mutans, type 1 diabetes mellitus

Yes

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Yes

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97

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https://pergamos.lib.uoa.gr/uoa/dl/object/1713893