Unit:
Library of the School of Health SciencesΤομέας Βασικών Επιστημών
Author:
Margetis Nikolaos
Dissertation committee:
1. Σκανδαλάκης Παναγιώτης, Καθηγητής, Τμήμα Ιατρικής, ΕΚΠΑ
2. Γοργούλης Βασίλειος, Καθηγητής, Τμήμα Ιατρικής, ΕΚΠΑ
3. Κλέτσας Δημήτριος, Διευθυντής Ερευνών, ΕΚΕΦΕ "Δημόκριτος"
4. Κουλούκουσα-Γιαννιού Μυρσίνη, Αναπληρώτρια Καθηγήτρια, Τμήμα Ιατρικής, ΕΚΠΑ
5. Κοτσίνας Αθανάσιος, Επίκουρος Καθηγητής, Τμήμα Ιατρικής, ΕΚΠΑ
6. Μαριόλης-Σαψάκος Θεόδωρος, Επίκουρος Καθηγητής, Τμήμα Νοσηλευτικής, ΕΚΠΑ
7. Χαβάκη Σοφία, Επίκουρη Καθηγήτρια, Τμήμα Ιατρικής, ΕΚΠΑ
Original Title:
Μελέτη των K-RAS μεταλλάξεων σε όλα τα στάδια ανάπτυξης του καρκίνου του παχέος εντέρου
Translated title:
The study of K-RAS mutations through all the stages of colorectal cancer development
Summary:
K-ras oncogene is a key factor in colorectal cancer. Based on published and our data we propose that K-ras could be the oncogene responsible for the inactivation of the tumor-suppressor gene APC, currently considered as the initial step in colorectal tumorigenesis. K-ras fulfills the criteria of the oncogene-induced DNA damage model, as it can provoke well established causes for inactivating tumor-suppressors, i.e. DNA double-strand breaks (causing allele deletion) and ROS production (responsible for point mutation). The model we propose is a variation of the current one and hypothesizes that, in a subgroup of colorectal carcinomas; K-ras mutation may precede APC inactivation, representing the earliest driving force and, probably, an early biomarker of colorectal carcinogenesis. This observation is clinically useful, since it may modify the preventive colorectal cancer strategy, restricting numerically patients undergoing colonoscopies to those bearing K-ras mutation in their colorectum, either in benign polyps or the normal accompanying mucosa.
Main subject category:
Health Sciences
Keywords:
K-ras mutation, Normal mucosa, Benign polyp, Earliest mutation, Biomarker, Colorectal cancer
Number of references:
202
