Supervisors info:
Σιάσος Γεράσιμος Αναπληρωτής Καθηγητής Ιατρική Σχολή ,ΕΚΠΑ
Κυρίτση Ελένη Καθηγήτρια Νοσηλευτικής ΤΕΙ Αθήνας
Τούσουλης Δημήτριος Καθηγητής Καρδιολογίας Ιατρική Σχολή, ΕΚΠΑ
Summary:
Introduction: The adverse prognosis of diabetic patients following an acute coronary syndrome is well known by many clinical studies
The target of the study is to investigate the association between blood glucose levels to the morbidity and mortality of diabetic patients with acute myocardial infarction. Prospective 10-year follow-up study.
Material and Method: Out of 1,000 consecutive patients hospitalized with ACS diagnosis in the First Cardiac Clinic of the General Hospital. Hippocrates, 494 suffered from diabetes and participated in the prospective epidemiological study 8-10 years. Serum glucose, total cholesterol, HDL cholesterol, and triglycerides were also measured in all participants using the chromatographic enzyme method in a Technicon RA-1000 automated analyzer
Results: The majority of the patients were male and the incidence of total mortality in 8 years approaches 30%. 54.6% of the sample developed generally fatal or non fatal incidence (re-hospitalizations for coronary artery disease, stroke, cardiac failure or cardiovascular death)
A rate of 8% died during hospitalization. Diabetic patients who died at the end of the 8-year follow-up were older, p<0,001 with less adherence to the Mediterranean diet standard, p = 0.004, with increased C reactive protein and B natriuretic peptide, p <0.001, respectively, decreased hematocrit, p <0.001, increased fasting glucose and impaired renal, p <0.001, p = 0.003.
The increased C reactive protein by 1 mg / dL during the admission of diabetic patients with acute coronary syndrome was associated with 1% increase of possibility of stroke during the first year after the appearance of acute coronary syndrome
Conclusions: A significant proportion of diabetic patients had an incidence during 10 years (50% overall and approximately 30% cardiovascular death). . Diabetic patients who died at the end of the 8-year follow-up were older, showed less adherence to the Mediterranean diet standard, had elevated C reactive protein and B natriuretic peptide during the admission, had reduced hematocrit, increased fasting glucose and impaired renal and cardiac function.
Key words: acute coronary syndrome, long-term mortality, diabetes mellitus, fasting glucose, C reactive protein, blood pressure, renal and cardiac function.
Keywords:
Acute coronary syndrome, Long-term mortality, Diabetes mellitus, Fasting glucose, C reactive protein, Blood pressure, Renal and cardiac function.