Basic research: Correlation of impedance threshold device use during cardiopulmonary resuscitation with acute ischaemic injury of the vital organs in a pediatric porcine model of cardiac arrest.

Doctoral Dissertation uoadl:2079509 206 Read counter

Unit:
Τομέας Υγείας - Μητέρας - Παιδιού
Library of the School of Health Sciences
Deposit date:
2017-11-01
Year:
2017
Author:
Niforopoulou Panagiota
Dissertation committee:
Σιαφάκα Ιωάννα, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Τζουμάκα-Μπακούλα Χρυσάνθη, Ομότιμη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Ιακωβίδου Νικολέττα, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Ξάνθος Θεόδωρος, Καθηγητής, Ιατρική Σχολή, Πανεπιστήμιο Κύπρου
Μπούτσικου Θεοδώρα, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Καπαρός Γεώργιος, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Στάικου Χρυσούλα, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Βασική έρευνα: Συσχέτιση της χρήσης της συσκευής ουδού εμπέδησης στην καρδιοαναπνευστική αναζωογόνηση με το βαθμό οξείας ισχαιμικής βλάβης των ζωτικών οργάνων σε ζωικό μοντέλο καρδιακής ανακοπής παιδιατρικών χοίρων.
Languages:
Greek
Translated title:
Basic research: Correlation of impedance threshold device use during cardiopulmonary resuscitation with acute ischaemic injury of the vital organs in a pediatric porcine model of cardiac arrest.
Summary:
Purpose: To assess whether use of Impedance Threshold Device (ITD) during Cardiopulmonary Resuscitation (CPR) reduces the degree of post-cardiac arrest Acute Kidney Injury (AKI), as a result of improved hemodynamics, in a porcine model of ventricular fibrillation (VF) cardiac arrest.
Methods: After 8min of untreated cardiac arrest, the animals were resuscitated either with a sham ITD (control group, n=8) or with an active ITD (ITD group, n=8). Adrenaline was administered every 4min and electrical defibrillation was attempted every 2min until return of spontaneous circulation (ROSC) or asystole. After ROSC, the animals were monitored for 6h under general anesthesia and then returned to their cages for a 48h observation, before euthanasia. Two novel biomarkers, Neutrophil Gelatinase-Associated Lipocalin (NGAL) in plasma and Interleukin-18 (IL-18) in urine, were measured at 2h, 4h, 6h, 24h and 48h post-ROSC, in order to assess the degree of AKI.
Results: ROSC was observed in 7 (87.5%) animals treated with the sham valve and 8 (100%) animals treated with the active valve (p=NS). However, more than twice as many animals survived at 48h in the ITD group (n=8, 100%) compared to the control group (n=3, 37.5%). Urine IL-18 and plasma NGAL levels were augmented post-ROSC in both groups, but they were significantly higher in the control group compared with the ITD group, at all measured time points.
Conclusion: Use of ITD during CPR improved hemodynamic parameters, increased 48h survival and decreased the degree of post-cardiac arrest AKI in the resuscitated animals.
Main subject category:
Health Sciences
Other subject categories:
Cardiovascular diseases
Keywords:
Cardiopulmonary resuscitation, Impedance threshold device, Acute kidney injury
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
219
Number of pages:
125
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