Unit:
ΠΜΣ Καρκίνος Πνεύμονα: Σύγχρονη Κλινικοεργαστηριακή Προσέγγιση και ΈρευναLibrary of the School of Health Sciences
Author:
Pavlidis Nektarios
Supervisors info:
Συρίγος , Καθηγητής , Ιατρική, ΕΚΠΑ
Πολίτη , Αναπληρώτρια Καθηγήτρια, Ιατρική, ΕΚΠΑ
Καλόφωνος , Καθηγητής, Ιατρική, Π.Π.
Original Title:
Η κλινική σημασία του Ki 67 στους νευροενδοκρινείς όγκους του πνεύμονα
Translated title:
Clinical significance of Ki67 in neuroendocrine lung tumors
Summary:
Ki67 as a proliferation marker was first used two decades ago to help clinicians in the treatment and the prognosis of cancer patients.
The purpose of the study was to show whether there is a correlation between the Ki67 proliferation marker with the progression free survival (PFS), the overall survival (OS), the age, the patient's physical condition, the type of cancer, with or without metastases and the stage of the disease.
This is a retrospective study that included patient envelopes from «Sotiria» University Hospital. In particular, from 2008 to 2014, 126 patients were studied, 77.0% of whom were men.
The results of the study showed that SCLC cancer patients had a higher risk of disease progression than AC cancer patients.
SCLC limited-stage had a 52% lower risk for disease progression compared to SCLC patients with extensive stage cancer.
Patients with bone metastasis had a higher risk of disease progression than those who did not have bone metastasis.
Patients with PS 2-3 were at higher risk compared to PS 0 patients.
SCLC cancer patients had a higher risk than AC cancer patients.
SCLC patients with a limited-stage cancer were 54% lower risk compared to SCLC patients with extensive stage cancer. Patients with metastasis in the brain were at higher risk compared to patients who did not have metastasis in the brain.
In conclusion, we can say that this is a study which showed that in patients with Neuroendocrine Lung Tumors there is a direct correlation between Ki67 (PFS) and (OS) the existence or absence of metastases (PS) of the patient, the type of cancer and stage.
Main subject category:
Health Sciences
Keywords:
Ki67, Clinical significance, Neuroendocrine tumors ,Lung cancer, Small cell carcinoma
