Vaginal probiotics preterm rupture of membranes

Doctoral Dissertation uoadl:2171318 199 Read counter

Τομέας Υγείας - Μητέρας - Παιδιού
Library of the School of Health Sciences
Deposit date:
Karampelas Alexios
Dissertation committee:
Αριστείδης Αντσακλής,Καθηγητης,Ιατρικής,ΕΚΠΑ
Λουτράδης Δημήτριος,Καθηγητης,Ιατρικής,ΕΚΠΑ
Παπαντωνίου Νικόλαος,Καθηγητης,Ιατρικής,ΕΚΠΑ
Δασκαλάκης Γεώργιος,Αναπληρωτής καθηγητης,Ιατρικής,ΕΚΠΑ
Παππα Καλλιόπη Επίκουρος καθηγητρια,Ιατρικής,ΕΚΠΑ
Θεοδωρά Μαριάννα, Λέκτωρας ,Ιατρικής,ΕΚΠΑ
Θωμάκος Νικόλαος, Επίκουρος καθηγητης,Ιατρικής,ΕΚΠΑ
Original Title:
Χορήγηση προβιοτικών στην πρόωρη ρήξη των εμβρυικών υμένων
Translated title:
Vaginal probiotics preterm rupture of membranes
Objective: To examine the influence of vaginal probiotic administration as an adjunct to standard antibiotic treatment on perinatal outcome in women with preterm premature rupture of membranes (PPROM).
Materials and Methods: This was a prospective randomized trial of cases with PPROM (24–34 weeks) that were admitted to our department between 2011 and 2015. Forty-nine cases received vaginal probiotics for 10 days in combination with antibiotic prophylaxis and were compared to 57 others that received only antibiotics for the same time period.
Results: The mean gestational age at birth (35.49 vs. 32.53 weeks), the mean duration of the latency period (5.60 vs. 2.48 weeks), and the mean birth weight (2,439.08 vs. 2,004.81 g) were significantly higher in the study group in comparison to the controls. Moreover, the neonates of the study group had a lower chance to enter the neonatal intensive care unit or the neonatal special care unit, shorter total hospitalization time, and lower need for oxygen administration and mechanical ventilation, as well as lower length of oxygen administration.
Conclusions: Vaginal probiotics as an adjunct to antibiotic prophylaxis in women with PPROM prolonged the latency period and improved the perinatal outcome.
Main subject category:
Health Sciences
Vaginal probiotics preterm premature rupture of membranes
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Alexios Karampelas - Phd Thesis.pdf
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