Contribution to the anatomical study of the sympathetic innervation of the peripheral arterioles of the limbs and their differences between the upper and lower limbs.

Doctoral Dissertation uoadl:2326526 689 Read counter

Unit:
Τομέας Βασικών Ιατρικών Επιστημών
Library of the School of Health Sciences
Deposit date:
2017-12-05
Year:
2017
Author:
Samolis Alexandros
Dissertation committee:
Μαρία Πιάγκου, Επίκουρη Καθηγήτρια, Ιατρική, ΕΚΠΑ
Παναγιώτης Σκανδαλάκης, Καθηγητής, Ιατρική, ΕΚΠΑ
Αντώνης Μαζαράκης, Αναπληρωτής Καθηγητής, Ιατρική, ΕΚΠΑ
Μυρσίνη Κουλούκουσα, Αναπληρώτρια Καθηγήτρια, Ιατρική, ΕΚΠΑ
Θεόδωρος Τρουπής, Αναπληρωτής Καθηγητής, Ιατρική, ΕΚΠΑ
Βασίλης Πρωτογέρου, Αναπληρωτής Καθηγητής, Ιατρική, ΕΚΠΑ
Κώστας Βλάσης, Αναπληρωτής Καθηγητής, Ιατρική, ΕΚΠΑ
Original Title:
Συμβολή στην ανατομική μελέτη της συμπαθητικής νεύρωσης των περιφερικών αρτηριδίων των άκρων και διαφορές αυτής στα άνω και κάτω άκρα.
Languages:
Greek
Translated title:
Contribution to the anatomical study of the sympathetic innervation of the peripheral arterioles of the limbs and their differences between the upper and lower limbs.
Summary:
The purpose of the current PhD dissertation is to enhance the knowledge of the sympathetic innervation of the peripheral arterioles of the limbs and to highlight the differences between the upper and lower limbs. The free sympathetic nerve fibers are extremely sensitive, so in a short period of time after the individual’s death, they lose their antigenicity. That is why all the published studies concerning the sympathetic innervation have been conducted exclusively in living. The plethora of measurements concerns the tibia, while the most stable measuring point is the thigh. The intraepidermal nerve fibers density (IENFD) is different at the upper and lower extremities. The mean value of IENFD is 21.38 fibers/mm for the thigh, 17.69 for the forearm, 12.89 for the tibia, 11.3 for the fingers and 6.5 for the toes. The IENFD decreases, when we are moving distally, and a gender dimorphism exists with females exceeding the IENFD in the tibia compared to males. The IENFD is affected by the radiation (positive correlation). The IENFD decreases with the advancing age and with the presence of neuropathy (mainly in diabetes and in acquired immune deficiency syndrome-HIV). In these diseases, there is a great reduction in sympathetic nerve fibers over the time. These results will support further studies to elucidate the increase and decrease of IENFD and their effect on disease, such as Raynaud phenomenon and other neurodegenerative diseases.
Main subject category:
Health Sciences
Keywords:
Sympathetic nervous system, Nerve fiber, Peripheral arterioles, Epidermal nerve fiber density, Limbs
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
225
Number of pages:
237
File:
File access is restricted.

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