Unit:
ΠΜΣ Καρκίνος Πνεύμονα: Σύγχρονη Κλινικοεργαστηριακή Προσέγγιση και ΈρευναLibrary of the School of Health Sciences
Supervisors info:
Ροβίνα Νικολέττα, Επίκ. Καθηγήτρια, Ιατρική, ΕΚΠΑ
Βασιλειάδης Ιωάννης,Επίκ. Καθηγητής,Ιατρική, ΕΚΠΑ
Κιαγιά Μαρία, Διδάκτωρ, Ιατρική, ΕΚΠΑ
Original Title:
Η σχέση του δείκτης μάζας σώματος και η επιβίωση ασθενών με μη μικροκυτταρικό καρκίνο πνεύμονα σταδίου IV
Translated title:
The relationship of bmi and survival of patients with non small cell lung cancer
Summary:
Τhe physique of patients before and after diagnosis of a disease, apart from regulating the chemotherapy administered, may alsoplay a significant roleinthe outcome. At the same time, it may also be a prognostic indicator of survival in patients with reduced, normal or increased body weight. A severe reduction in body mass index may be an inhibitory factor in the continuation of treatment but also determine the overall survival of patients.
Weight loss, which is a major feature of cancer cachexia, hasbeenidentified asa prognostic factor in cancer patients. Many studies have shown that weight loss is an important prognostic indicator of reduced survival. In particular, shorter life expectancy has been observed in patients with somatic protein depletion,as has been assessed in-vitro. Dual Energy X-ray Absortiometry shows that skeletal muscle loss is predictive of worse survival rates in men with advanced solid tumors.
In addition, patients undergoing chemotherapy have a reduced quality of life, are readmitted more frequently to the hospital and hospitalized for prolonged periods if they are malnourished while undergoing oncology therapy. Finally, 4-23% of patients with incurable types of cancer pass away due to progressive malnutrition and undernutrition.
In chronic diseases, high rates of synthesis and breakdown of whole body proteins have been reported. Most of these diseases are characterized by enhanced and systematic production of cytokines, typicalof chronic inflammatory conditions. The result of the increased production of acute phase proteins may explain the observed increase in protein degradation and synthesisrate indicating a relationship between the increased rate of protein degradation and synthesisand the inflammation.
The effects of cancer depend to a considerable extent on the type of cancer, its location and its potential metastases. The loss of weight caused by cancer due to negative nutritional balance and inflammation determines the effects on protein kinetics and whether the occurrence of cachexia is caused early, late or not at all.
The correlation between malnutrition and poor survival does not automatically mean that improving the nutritional status will also produce a better result. However , there is evidence that drastic treatment of malnutrition may be beneficial. It has been shown that malnourished patients undergoing chemotherapy have a lower tolerance to it as far as duration and frequently are concerned. Sufficient oncology treatment clearly plays a major role in determining the prognosis of curable tumors.
In the study presented in this paper an attempt was made to correlate the body mass index with the survival of patients with non-small cell lung cancer stage IV.
Main subject category:
Health Sciences
Keywords:
BMI, Cahexia, Survival, NSCLC
File:
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Roidis Ioannis Master.pdf
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