Circadian rhythms in adrenal adenomas and their relation to the presence of osteopenia and osteoporosis

Postgraduate Thesis uoadl:2739629 417 Read counter

Unit:
ΠΜΣ Μεταβολικά Νοσήματα των Οστών
Library of the School of Health Sciences
Deposit date:
2018-04-17
Year:
2018
Author:
Katsoulis Konstantinos
Supervisors info:
Γεώργιος Λυρίτης, Καθηγητής, Ιατρική, ΕΚΠΑ
Δοντά Ισμήνη-Νίκη, Καθηγήτρια, Ιατρική, ΕΚΠΑ
Τριανταφυλλόπουλος Ιωάννης, Επίκουρος Καθηγητής, Ιατρική, ΕΚΠΑ
Original Title:
Κιρκάδιοι ρυθμοί στα αδενώματα των επινεφριδίων και η συσχέτισή τους με την παρουσία οστεοπενίας και οστεοπόρωσης
Languages:
Greek
Translated title:
Circadian rhythms in adrenal adenomas and their relation to the presence of osteopenia and osteoporosis
Summary:
Abstract
Background: It is known that humans live under the strong influence of light/dark cycles associated with the day/ night changes created by the 24-hour rotation of the earth. Yet, it is possible that the circadian rhythm could be disrupted from the presence of a disease and/or changes in body homeostasis. The aim of the present study was to search for an association in patients with adrenal adenomas between cortisol circadian rhythm and osteopathies.
Materials and Methods: Twenty-eight patients participated and the presence of adrenal adenoma, osteopathy or both was recorded. Patients were tested for routine biochemical factors as well as cortisol levels at 8 a.m., 1 p.m., 5 p.m. and 11 p.m., as well as ACTH and urine cortisol.
Results: Significant differences were observed in SGOT, Free-T4, FSH levels, with subjects without history of osteopenia or osteoporosis manifesting lower levels as compared to subjects with a history of osteopenia or osteoporosis. On the other hand, K+ levels manifested the opposite behaviour. At the same time cortisol remained similar among all patient groups.
Discussion: Although there is no conclusive evidence, cortisol levels appear to remain untouched by the disease states and thus it appears that circadian rhythms are regulated through an alternative circuitry.
Main subject category:
Health Sciences
Keywords:
Osteopenia, Osteoporosis, Adenoma, Cortisol, Circadian rhythm
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
36
Number of pages:
249
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