Κατεύθυνση Έρευνα στην Γυναικεία ΑναπαραγωγήLibrary of the School of Health Sciences
Δέσποινα Περρέα, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Παύλος Πατάπης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Δημήτριος Δημητρούλης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
gamma-H2AX: είναι δυνατή η καθιέρωσή του ως κλασικoύ καρκινικού προγνωστικού δείκτη;
gamma-H2AX: Can it be established as a classical cancer prognostic factor?
Double-strand breaks are among the first procedures taking place in cancer formation and progression as a result of endogenic and exogenic factors. The histone variant H2AX undergoes phosphorylation at serine 139 due to double- strand breaks, and the gamma-H2AX is formatted as a result of genomic instability. The detection of gamma-H2AX can potentially serve as a biomarker for transformation of normal tissue to premalignant and consequently to malignant tissues. gamma-H2AX has already been investigated in a variety of cancer types, including breast, lung, colon, cervix, and ovary cancers. The prognostic value of gamma-H2AX is indicated in certain cancer types, such as breast or endometrial cancer, but further investigation is needed to establish gamma-H2AX as a prognostic marker. This review outlines the role of gamma-H2AX in cell cycle, and its formation as a result of DNA damage. We investigate the role of gamma- H2AX formation in several cancer types and its correlation with other prognostic factors, and we try to find out whether it fulfills the requirements for its establishment as a classical cancer prognostic factor.
Main subject category:
gH2AX, Cancer, Histones, Prognosis, DNA damage
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