Ν. Καβαντζάς, Καθηγητής, Ιατρική, ΕΚΠΑ
Ε. Πρωτόπαπα, Καθηγήτρια, Ιατρική, ΕΚΠΑ
Α. Λάζαρης, Καθηγητής, Ιατρική, ΕΚΠΑ
Μelanoma is a malignant tumor originating from melanocytes, the cells that produce skin
pigmentation (melanin). It is found on the skin and the mucous membranes.
The main risk factor for the development of melanoma is the excessive exposure to solar
radiation. Ultraviolet radiation causes mutations in the cellular DNA, which can gradually
lead to melanoma.
Individuals, with inherited redisposing factors and with dysplastic and large numbers of nondysplastic
pigmented moles in their bodies, face an increased risk of developing melanoma
The clinical diagnosis of melanoma is made from the following specific points:
A- (asymmetry) the asymmetry of the shape of the pigmented lesion
B- (border) the uneven limits of the fault
C- (color) the change of the color and the variegation of the pigment damage
D- (diameter) the increase in the damage diameter of more than 6mm
Also, symptoms such as pain, itching, bleeding and an increase in the size and also tumor
formation, are strong indications for the malignant transformation of a melanocytic nevous.
Early diagnosis and timely treatment contribute substantially to the likelihood of healing.
However, the important role of prevention should not be underestimated. Precautions
should be taken to prevent the inappropriate exposure to sunlight, while sun protection
measures should be taken throughout the year, particularly by those who belong in the highrisk