Supervisors info:
Βασιλική Οικονομίδου, Επίκουρη Καθηγήτρια, Τμήμα Βιολογίας, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Summary:
Autoimmune diseases are currently a major cause of chronic diseases. In practice, there are more than 100 different types of autoimmune diseases. They are an important clinical problem due to their chronic nature, the cost of health care and their manifestation in young people. Current treatments, although seemingly promising to treat some autoimmune diseases, do not address the underlying problems that are responsible for their onset and progression. Treating these diseases requires an understanding of the mechanisms that trigger the various abnormal immune responses.
The aim of this work was to study the blood autoimmune diseases, namely pernicious anemia, autoimmune neutropenia, primary acquired pure red cell aplasia, paroxysmal nocturnal hemoglobinuria, idiopathic thrombocytopenic purpura, autoimmune lymphoproliferative syndrome, acquired aplastic anemia, antiphospholipid syndrome and autoimmune hemolytic anemia. For this purpose, all proteins associated with these diseases and their interactions were collected, and a systematic network approach to study their relationships was conducted.
We were able to find proteins associated with these autoimmune diseases, and through the investigation of their interactions, we created, analyzed and studied their interaction networks. We managed to identify candidate proteins involved in their pathogenesis, and distinguish other important proteins, which may play an important role in blood autoimmune diseases.
Keywords:
autoimmune diseases, pernicious anemia, autoimmune neutropenia, primary acquired pure red cell aplasia, paroxysmal nocturnal hemoglobinuria, autoimmune thrombocytopenic purpura, autoimmune lymphoproliferative syndrome, acquired aplastic anemia, antiphospholipid syndrome, autoimmune hemolytic anemia
